BIOMAT Database Logo BIOMAT Database Logo

Neutralising antibodies to West Nile virus detected in horses in Windhoek, Namibia. 2022

U Molini, and G Franzo, and I Rautenbach, and H V Otto, and S Khaiseb, and A Di Gennaro, and C Ntahonshikira, and I Baines, and F Monaco, and G Savini, and N D'Alterio
Department of Para-Clinical Studies, School of Veterinary Medicine, Faculty of Health Sciences and Veterinary Medicine, University of Namibia, Namibia and Department of Biotechnology, Central Veterinary Laboratory, Namibia.

West Nile virus (WNV) is a vector-borne virus maintained in nature by a bird-mosquito cycle. However, it can occasionally and accidentally infect horses and human beings, leading to sometimes severe or even fatal outcomes in these species. Therefore, the monitoring of its circulation and disease occurrence is of relevance. Unfortunately, it is underdiagnosed or not diagnosed in several African counties, including Namibia, where no data is currently available for horses. In this study, 98 horses in three different stables in the Windhoek city area were investigated. They were found to have a seroprevalence of approximately 7%. Positive reactions were seen at all three stables, suggesting a greater than expected prevalence of the virus. This is the first report of serological evidence for the presence of the virus in horses in Nambia. Even though clinical signs were not reported in any of the stables from which the sera were derived, the seroprevalence to the virus suggests that horses with high genetic and/or economic value could benefit from vaccination against WNV. Because of the zoonotic potential of the virus, these findings are also of significance to human health authorities.

UI MeSH Term Description Entries
D009276 Namibia A republic in southern Africa, south of ANGOLA and west of BOTSWANA. Its capital is Windhoek. Republic of Namibia,South West Africa,Southwest Africa
D006734 Horse Diseases Diseases of domestic and wild horses of the species Equus caballus. Equine Diseases,Disease, Equine,Disease, Horse,Diseases, Equine,Diseases, Horse,Equine Disease,Horse Disease
D006736 Horses Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest. Equus caballus,Equus przewalskii,Horse, Domestic,Domestic Horse,Domestic Horses,Horse,Horses, Domestic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000914 Antibodies, Viral Immunoglobulins produced in response to VIRAL ANTIGENS. Viral Antibodies
D014901 West Nile Fever A mosquito-borne viral illness caused by the WEST NILE VIRUS, a FLAVIVIRUS and endemic to regions of Africa, Asia, and Europe. Common clinical features include HEADACHE; FEVER; maculopapular rash; gastrointestinal symptoms; and lymphadenopathy. MENINGITIS; ENCEPHALITIS; and MYELITIS may also occur. The disease may occasionally be fatal or leave survivors with residual neurologic deficits. (From Joynt, Clinical Neurology, 1996, Ch26, p13; Lancet 1998 Sep 5;352(9130):767-71) Kunjin virus Infection,Encephalitis, West Nile Fever,WNV Infection,West Nile Fever Encephalitis,West Nile Fever Meningitis,West Nile Fever Meningoencephalitis,West Nile Fever Myelitis,West Nile Virus Infection,Infection, Kunjin virus,Infection, WNV,Kunjin virus Infections,WNV Infections
D014902 West Nile virus A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE). It can infect birds and mammals. In humans, it is seen most frequently in Africa, Asia, and Europe presenting as a silent infection or undifferentiated fever (WEST NILE FEVER). The virus appeared in North America for the first time in 1999. It is transmitted mainly by CULEX spp mosquitoes which feed primarily on birds, but it can also be carried by the Asian Tiger mosquito, AEDES albopictus, which feeds mainly on mammals. Egypt 101 virus,Kunjin virus
D016036 Seroepidemiologic Studies EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases. Seroprevalence,Seroepidemiologic Study,Seroepidemiological Study,Studies, Seroepidemiologic,Study, Seroepidemiologic,Seroepidemiological Studies,Seroprevalences,Studies, Seroepidemiological,Study, Seroepidemiological
D057134 Antibodies, Neutralizing Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus. Neutralizing Antibodies,Antibody, Neutralizing,Neutralizing Antibody

Related Publications

U Molini, and G Franzo, and I Rautenbach, and H V Otto, and S Khaiseb, and A Di Gennaro, and C Ntahonshikira, and I Baines, and F Monaco, and G Savini, and N D'Alterio
Neutralising antibodies for West Nile virus in horses from Brazilian Pantanal.
June 2011, Memorias do Instituto Oswaldo Cruz,
U Molini, and G Franzo, and I Rautenbach, and H V Otto, and S Khaiseb, and A Di Gennaro, and C Ntahonshikira, and I Baines, and F Monaco, and G Savini, and N D'Alterio
Sindbis virus neutralising antibodies detected in Swedish horses.
June 2021, One health (Amsterdam, Netherlands),
U Molini, and G Franzo, and I Rautenbach, and H V Otto, and S Khaiseb, and A Di Gennaro, and C Ntahonshikira, and I Baines, and F Monaco, and G Savini, and N D'Alterio
West Nile virus antibodies in Colombian horses.
September 2005, Emerging infectious diseases,
U Molini, and G Franzo, and I Rautenbach, and H V Otto, and S Khaiseb, and A Di Gennaro, and C Ntahonshikira, and I Baines, and F Monaco, and G Savini, and N D'Alterio
West Nile virus in horses.
November 2006, The Veterinary record,
U Molini, and G Franzo, and I Rautenbach, and H V Otto, and S Khaiseb, and A Di Gennaro, and C Ntahonshikira, and I Baines, and F Monaco, and G Savini, and N D'Alterio
West Nile virus in horses.
December 2006, The Veterinary record,
U Molini, and G Franzo, and I Rautenbach, and H V Otto, and S Khaiseb, and A Di Gennaro, and C Ntahonshikira, and I Baines, and F Monaco, and G Savini, and N D'Alterio
West Nile virus in horses.
December 2006, The Veterinary record,
U Molini, and G Franzo, and I Rautenbach, and H V Otto, and S Khaiseb, and A Di Gennaro, and C Ntahonshikira, and I Baines, and F Monaco, and G Savini, and N D'Alterio
West Nile virus in horses.
January 2006, The Veterinary record,
U Molini, and G Franzo, and I Rautenbach, and H V Otto, and S Khaiseb, and A Di Gennaro, and C Ntahonshikira, and I Baines, and F Monaco, and G Savini, and N D'Alterio
Detection of antibodies to West Nile virus in horses, Costa Rica, 2004.
August 2011, Vector borne and zoonotic diseases (Larchmont, N.Y.),
U Molini, and G Franzo, and I Rautenbach, and H V Otto, and S Khaiseb, and A Di Gennaro, and C Ntahonshikira, and I Baines, and F Monaco, and G Savini, and N D'Alterio
Serum antibodies to West Nile virus in naturally exposed and vaccinated horses.
September 2008, Journal of medical microbiology,
U Molini, and G Franzo, and I Rautenbach, and H V Otto, and S Khaiseb, and A Di Gennaro, and C Ntahonshikira, and I Baines, and F Monaco, and G Savini, and N D'Alterio
West Nile virus in horses, Guatemala.
June 2006, Emerging infectious diseases,
Copied contents to your clipboard!