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An 18-year-old girl developed cheilitis. She had a past history of lip cream dermatitis, but the cause was not found. Patch tests with 2 lipsticks were strongly positive. Tests with the ingredients were positive to 2 aliphatic compounds, glyceryl diisostearate and diisostearyl malate. Impurities in the materials were suspected as the cause. Analysis by gas chromatography detected 3 chemicals in glyceryl diisostearate and 1 in diisostearyl malate as impurities. Patch testing with the impurities and glyceryl monoisostearate 0.01% pet in glyceryl diisostearate and isostearyl alcohol 0.25% pet in diisostearyl malate were strongly positive. The characteristics common to the 2 chemicals were liquidity at room temperature, branched C18 aliphatic compound and primary alcohol. Chemicals lacking any of the above 3 features did not react.
R Hayakawa, and
K Matsunaga, and
M Suzuki, and
Y Arima, and
Y Ohkido
April 1980,
Contact dermatitis,
R Hayakawa, and
K Matsunaga, and
M Suzuki, and
Y Arima, and
Y Ohkido
October 1953,
Journal of the Irish Medical Association,
R Hayakawa, and
K Matsunaga, and
M Suzuki, and
Y Arima, and
Y Ohkido
February 1958,
Zeitschrift fur Haut- und Geschlechtskrankheiten,
R Hayakawa, and
K Matsunaga, and
M Suzuki, and
Y Arima, and
Y Ohkido
August 1999,
Contact dermatitis,
R Hayakawa, and
K Matsunaga, and
M Suzuki, and
Y Arima, and
Y Ohkido
August 1999,
Contact dermatitis,
R Hayakawa, and
K Matsunaga, and
M Suzuki, and
Y Arima, and
Y Ohkido
July 1984,
Contact dermatitis,
R Hayakawa, and
K Matsunaga, and
M Suzuki, and
Y Arima, and
Y Ohkido
October 1984,
Contact dermatitis,
R Hayakawa, and
K Matsunaga, and
M Suzuki, and
Y Arima, and
Y Ohkido
January 1952,
Annales de dermatologie et de syphiligraphie,
R Hayakawa, and
K Matsunaga, and
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Y Arima, and
Y Ohkido
January 2003,
Cardiology,
R Hayakawa, and
K Matsunaga, and
M Suzuki, and
Y Arima, and
Y Ohkido
December 1951,
Rassegna medica,
