Biomaterial Database

The cat infected with Brugia pahangi as a model of human filariasis. 1987

D A Denham, and C Fletcher

The responses of cats to Brugia pahangi, which parasitizes them in nature, mimic those of humans to Brugia malayi and Wuchereria bancrofti in many important respects. It is likely that many of the features of the relationship between host and parasite that can be studied in cats infected with B. pahangi also apply to humans, but for a variety of practical reasons cannot be demonstrated in humans. Both immunologically and parasitologically there is a profound difference between B. pahangi-infected cats that have microfilariae in their blood and those that either do not become microfilaraemic or clear their blood of microfilariae and become post-microfilaraemic. Microfilaraemic cats are susceptible to reinfection and fail to recognize the surface of the sheath of microfilariae. They also do not produce antibodies against several components recognized by post-microfilaraemic cats. Cats that have destroyed their microfilariae also destroy their adult worms and are very resistant to challenge with infective larvae. Apart from the unique ability to recognize the sheath of microfilariae in fluorescent antibody tests, sera from these cats react with microfilarial antigens at 61-81 kDa, antigens of infective larvae at 22 and 18.5 kDa and adult antigens at 34, 18, 16, 13 and 11.5 kDa. None of these antigens are recognized by microfilaraemic cats.

UI	MeSH Term	Description	Entries
D008209	Lymphedema	Edema due to obstruction of lymph vessels or disorders of the lymph nodes.	Milroy's Disease,Congenital Familial Lymphedema,Congenital Hereditary Lymphedema,Early Onset Lymphedema,Hereditary Lymphedema,Hereditary Lymphedema 1,Hereditary Lymphedema Type I,Lymphedema, Early-Onset,Lymphedema, Hereditary, Ia,Milroy Disease,Nonne-Milroy Disease,Nonne-Milroy Lymphedema,Nonne-Milroy-Meige Disease,Primary Congenital Lymphedema,Congenital Hereditary Lymphedemas,Congenital Lymphedema, Primary,Congenital Lymphedemas, Primary,Early Onset Lymphedemas,Early-Onset Lymphedema,Early-Onset Lymphedemas,Hereditary Lymphedema 1s,Hereditary Lymphedema, Congenital,Hereditary Lymphedemas,Hereditary Lymphedemas, Congenital,Lymphedema, Congenital Hereditary,Lymphedema, Early Onset,Lymphedema, Hereditary,Lymphedema, Nonne-Milroy,Lymphedema, Primary Congenital,Lymphedemas,Lymphedemas, Congenital Hereditary,Lymphedemas, Early Onset,Lymphedemas, Early-Onset,Lymphedemas, Hereditary,Lymphedemas, Primary Congenital,Milroys Disease,Nonne Milroy Disease,Nonne Milroy Lymphedema,Nonne Milroy Meige Disease,Primary Congenital Lymphedemas
D008842	Microfilariae	The prelarval stage of Filarioidea found in the blood and tissues of mammals, birds and intermediate hosts (vector).	Microfilaria
D002009	Brugia	A filarial worm of Southeast Asia, producing filariasis and elephantiasis in various mammals including man. It was formerly included in the genus WUCHERERIA.	Brugias
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004605	Elephantiasis, Filarial	Parasitic infestation of the human lymphatic system by WUCHERERIA BANCROFTI or BRUGIA MALAYI. It is also called lymphatic filariasis.	Bancroftian Elephantiasis,Brugian Filariasis,Brugoa malayi Infection,Elephantiasis, Bancroftian,Filarial Elephantiasis,Filariasis, Lymphatic,Lymphatic Filariasis,Wuchereria bancrofti Infection,Bancroftian Filariasis,Elephantiasis, Malayi,Malayi Filariasis,Bancroftian Elephantiases,Bancroftian Filariases,Brugian Filariases,Brugoa malayi Infections,Filarial Elephantiases,Filariasis, Bancroftian,Filariasis, Brugian,Filariasis, Malayi,Infection, Brugoa malayi,Infection, Wuchereria bancrofti,Lymphatic Filariases,Malayi Elephantiases,Malayi Elephantiasis,Malayi Filariases,Wuchereria bancrofti Infections
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000917	Antibody Formation	The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.	Antibody Production,Antibody Response,Antibody Responses,Formation, Antibody,Production, Antibody,Response, Antibody,Responses, Antibody
D000947	Antigens, Helminth	Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.	Helminth Antigens