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A randomized, double-blind controlled trial of low-dose heparin combined with sulfinpyrazone to prevent deep-vein thrombosis after operation on the hip was carried out. In a group of seventy-three patients after arthroplasty, postoperative thrombosis of the veins of the lower limbs occurred in 51 per cent of the control patients and in 36 per cent of the treated patients. In a fracture group of thirty patients, thrombosis occurred in 75 per cent of the control patients and in 36 per cent of the treated patients. These differences are of borderline statistical significance in the fracture group and are of no statistical significance in the arthroplasty group. However, a 36 per cent incidence of venous thrombosis in the drug-treated patients is too high to justify recommendation of the regimen tested without careful monitoring of patients by tests designed to detect thrombosis. Then, appropriate anticoagulant therapy can be instituted if necessary.
P H Rogers, and
P N Walsh, and
V J Marder, and
G C Bosak, and
J W Lachman, and
W G Ritchie, and
L Oppenheimer, and
S Sherry
January 2015,
Thrombosis and haemostasis,
P H Rogers, and
P N Walsh, and
V J Marder, and
G C Bosak, and
J W Lachman, and
W G Ritchie, and
L Oppenheimer, and
S Sherry
June 1993,
The Journal of bone and joint surgery. American volume,
P H Rogers, and
P N Walsh, and
V J Marder, and
G C Bosak, and
J W Lachman, and
W G Ritchie, and
L Oppenheimer, and
S Sherry
March 1983,
American journal of obstetrics and gynecology,
P H Rogers, and
P N Walsh, and
V J Marder, and
G C Bosak, and
J W Lachman, and
W G Ritchie, and
L Oppenheimer, and
S Sherry
January 1979,
Acta chirurgica Scandinavica,
P H Rogers, and
P N Walsh, and
V J Marder, and
G C Bosak, and
J W Lachman, and
W G Ritchie, and
L Oppenheimer, and
S Sherry
October 1980,
American journal of obstetrics and gynecology,
P H Rogers, and
P N Walsh, and
V J Marder, and
G C Bosak, and
J W Lachman, and
W G Ritchie, and
L Oppenheimer, and
S Sherry
June 1976,
Modern concepts of cardiovascular disease,
P H Rogers, and
P N Walsh, and
V J Marder, and
G C Bosak, and
J W Lachman, and
W G Ritchie, and
L Oppenheimer, and
S Sherry
December 1978,
The Journal of bone and joint surgery. American volume,
P H Rogers, and
P N Walsh, and
V J Marder, and
G C Bosak, and
J W Lachman, and
W G Ritchie, and
L Oppenheimer, and
S Sherry
October 1974,
Lancet (London, England),
P H Rogers, and
P N Walsh, and
V J Marder, and
G C Bosak, and
J W Lachman, and
W G Ritchie, and
L Oppenheimer, and
S Sherry
August 1975,
The New England journal of medicine,
P H Rogers, and
P N Walsh, and
V J Marder, and
G C Bosak, and
J W Lachman, and
W G Ritchie, and
L Oppenheimer, and
S Sherry
January 2007,
World journal of surgery,
