Biomaterial Database

80 Hz but not 40 Hz, transcranial alternating current stimulation of 80 Hz over right intraparietal sulcus increases visuospatial working memory capacity. 2022

Jimin Park, and Chany Lee, and Sangjun Lee, and Chang-Hwan Im

Department of Biomedical Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea.

Working memory (WM) is a complex cognitive function involved in the temporary storage and manipulation of information, which has been one of the target cognitive functions to be restored in neurorehabilitation. WM capacity is known to be proportional to the number of gamma cycles nested in a single theta cycle. Therefore, gamma-band transcranial alternating current stimulation (tACS) should be dependent of the stimulation frequency; however, the results of previous studies that employed 40 Hz tACS have not been consistent. The optimal locations and injection currents of multiple scalp electrodes were determined based on numerical simulations of electric field. Experiments were conducted with 20 healthy participants. The order of three stimulation conditions (40 Hz tACS, 80 Hz tACS, and sham stimulation) were randomized but counterbalanced. Visual hemifield-specific visual WM capacity was assessed using a delayed visual match to the sample task. High gamma tACS significantly increased WM capacity, while low gamma tACS had no significant effect. Notably, 80 Hz tACS increased WM capacity on both the left and right visual hemifields, while previous tACS studies only reported the effects of tACS on contralateral hemifields. This is the first study to investigate the frequency-dependent effect of gamma-band tACS on WM capacity. Our findings also suggest that high gamma tACS might influence not only WM capacity but also communication between interhemispheric cortical regions. It is expected that high gamma tACS could be a promising neurorehabilitation method to enhance higher-order cognitive functions with similar mechanisms.

UI	MeSH Term	Description	Entries
D008570	Memory, Short-Term	Remembrance of information for a few seconds to hours.	Immediate Recall,Memory, Immediate,Working Memory,Memory, Shortterm,Immediate Memories,Immediate Memory,Immediate Recalls,Memories, Immediate,Memories, Short-Term,Memories, Shortterm,Memory, Short Term,Recall, Immediate,Recalls, Immediate,Short-Term Memories,Short-Term Memory,Shortterm Memories,Shortterm Memory,Working Memories
D010296	Parietal Lobe	Upper central part of the cerebral hemisphere. It is located posterior to central sulcus, anterior to the OCCIPITAL LOBE, and superior to the TEMPORAL LOBES.	Brodmann Area 39,Brodmann Area 40,Brodmann Area 5,Brodmann Area 7,Brodmann's Area 39,Brodmann's Area 40,Brodmann's Area 5,Brodmann's Area 7,Inferior Parietal Cortex,Secondary Sensorimotor Cortex,Superior Parietal Lobule,Angular Gyrus,Gyrus Angularis,Gyrus Supramarginalis,Intraparietal Sulcus,Marginal Sulcus,Parietal Cortex,Parietal Lobule,Parietal Region,Posterior Paracentral Lobule,Posterior Parietal Cortex,Praecuneus,Precuneus,Precuneus Cortex,Prelunate Gyrus,Supramarginal Gyrus,Area 39, Brodmann,Area 39, Brodmann's,Area 40, Brodmann,Area 40, Brodmann's,Area 5, Brodmann,Area 5, Brodmann's,Area 7, Brodmann,Area 7, Brodmann's,Brodmanns Area 39,Brodmanns Area 40,Brodmanns Area 5,Brodmanns Area 7,Cortex, Inferior Parietal,Cortex, Parietal,Cortex, Posterior Parietal,Cortex, Precuneus,Cortex, Secondary Sensorimotor,Cortices, Inferior Parietal,Gyrus, Angular,Gyrus, Prelunate,Gyrus, Supramarginal,Inferior Parietal Cortices,Lobe, Parietal,Lobule, Parietal,Lobule, Posterior Paracentral,Lobule, Superior Parietal,Paracentral Lobule, Posterior,Paracentral Lobules, Posterior,Parietal Cortex, Inferior,Parietal Cortex, Posterior,Parietal Cortices,Parietal Cortices, Inferior,Parietal Cortices, Posterior,Parietal Lobes,Parietal Lobule, Superior,Parietal Lobules,Parietal Lobules, Superior,Parietal Regions,Posterior Paracentral Lobules,Posterior Parietal Cortices,Precuneus Cortices,Region, Parietal,Secondary Sensorimotor Cortices,Sensorimotor Cortex, Secondary,Superior Parietal Lobules
D003071	Cognition	Intellectual or mental process whereby an organism obtains knowledge.	Cognitive Function,Cognitions,Cognitive Functions,Function, Cognitive,Functions, Cognitive
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D064368	Healthy Volunteers	Persons with no known significant health problems who are recruited to participate in research to test a new drug, device, or intervention as controls for a patient group. (from http://clinicalcenter.nih.gov/recruit/volunteers.html, accessed 2/14/2013)	Healthy Participants,Healthy Subjects,Human Volunteers,Normal Volunteers,Healthy Participant,Healthy Subject,Healthy Volunteer,Human Volunteer,Normal Volunteer,Participant, Healthy,Participants, Healthy,Subject, Healthy,Subjects, Healthy,Volunteer, Healthy,Volunteer, Human,Volunteer, Normal,Volunteers, Human,Volunteers, Normal
D065908	Transcranial Direct Current Stimulation	A technique of brain electric stimulation therapy which uses constant, low current delivered via ELECTRODES placed on various locations on the scalp.	Anodal Stimulation Transcranial Direct Current Stimulation,Anodal Stimulation tDCS,Cathodal Stimulation Transcranial Direct Current Stimulation,Cathodal Stimulation tDCS,Repetitive Transcranial Electrical Stimulation,Transcranial Alternating Current Stimulation,Transcranial Electrical Stimulation,Transcranial Random Noise Stimulation,tDCS,Anodal Stimulation tDCSs,Cathodal Stimulation tDCSs,Electrical Stimulation, Transcranial,Electrical Stimulations, Transcranial,Stimulation tDCS, Anodal,Stimulation tDCS, Cathodal,Stimulation tDCSs, Anodal,Stimulation tDCSs, Cathodal,Stimulation, Transcranial Electrical,Stimulations, Transcranial Electrical,Transcranial Electrical Stimulations,tDCS, Anodal Stimulation,tDCS, Cathodal Stimulation,tDCSs, Anodal Stimulation,tDCSs, Cathodal Stimulation