Cationic water-based polyurethane(CWPU) was synthesized to explore aloe-emodin modifies to obtain CWPU materials with better comprehensive performance. It provides a simple way to synthesize antibacterial waterborne polyurethane, which is to introduce the end-blocking group of herbal extracts into the structure. It contains synergistic antibacterial effect of herbal antibacterial and quaternary ammonium ion on Escherichia coli. It makes the material resist the erosion of bacterial, and increase the service life of materials. When the pH value of the environment changes, the UV absorbance of the aloe-emodin modified cationic water-based polyurethane(AE-CWPU) also changes. Therefore, within a certain detection range, AE-CWPU has great applications in the field of smart response materials. The modified thermodynamic properties have been improved, and the mechanical properties basically maintained the maximum stress, and the elongation at break was reduced.