BIOMAT Database Logo BIOMAT Database Logo

Effect of an iron chelator on the onset of hexachlorobenzene-induced porphyria in rats. 1986

R Wainstok de Calmanovici, and S C Billi, and C A Aldonatti, and L C San Martín de Viale

The effect of desferrioxamine on hexachlorobenzene (HCB)-induced porphyria was studied in female rats in order to investigate the role of iron in the development of this porphyria. Repeated injections of desferrioxamine delayed and remarkably diminished the urinary excretion of precursors and porphyrins and the accumulation of porphyrins in the liver. These effects were produced because the desferrioxamine attenuated the alterations produced by HCB in two key enzymes: porphyrinogen carboxy-lyase and delta-aminolaevulinic acid synthase. The effect of desferrioxamine on both enzymes was also studied in vitro. This work showed that iron plays an important role in the onset of HCB-induced porphyria and supplied information on the mechanism of action. A common iron-involving mechanism for the production of porphyria by different chlorinated compounds is suggested.

UI MeSH Term Description Entries
D007502 Iron Chelating Agents Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems. Iron Chelates,Agents, Iron Chelating,Chelates, Iron,Chelating Agents, Iron
D011164 Porphyrias A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues. Porphyria,Porphyrin Disorder,Disorder, Porphyrin,Disorders, Porphyrin,Porphyrin Disorders
D002262 Carboxy-Lyases Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1. Carboxy-Lyase,Decarboxylase,Decarboxylases,Carboxy Lyase,Carboxy Lyases
D002722 Chlorobenzenes Aromatic organic compounds with the chemical formula C6H5Cln.
D003676 Deferoxamine Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form. Desferrioxamine,Deferoxamine B,Deferoxamine Mesilate,Deferoxamine Mesylate,Deferoxamine Methanesulfonate,Deferoximine,Deferrioxamine B,Desferal,Desferioximine,Desferrioxamine B,Desferrioxamine B Mesylate,Desferroxamine,Mesilate, Deferoxamine,Mesylate, Deferoxamine,Mesylate, Desferrioxamine B,Methanesulfonate, Deferoxamine
D004790 Enzyme Induction An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis. Induction, Enzyme
D005260 Female Females
D006581 Hexachlorobenzene An agricultural fungicide and seed treatment agent. HCB
D000624 5-Aminolevulinate Synthetase An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37. Aminolevulinic Acid Synthetase,delta-Aminolevulinate Synthase,5-Aminolevulinate Synthase,delta-Aminolevulinic Acid Synthetase,5 Aminolevulinate Synthase,5 Aminolevulinate Synthetase,Acid Synthetase, Aminolevulinic,Acid Synthetase, delta-Aminolevulinic,Synthase, 5-Aminolevulinate,Synthase, delta-Aminolevulinate,Synthetase, 5-Aminolevulinate,Synthetase, Aminolevulinic Acid,Synthetase, delta-Aminolevulinic Acid,delta Aminolevulinate Synthase,delta Aminolevulinic Acid Synthetase
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

R Wainstok de Calmanovici, and S C Billi, and C A Aldonatti, and L C San Martín de Viale
Iron absorption during the development of hexachlorobenzene-induced porphyria in rats.
January 1982, Archives of dermatological research,
R Wainstok de Calmanovici, and S C Billi, and C A Aldonatti, and L C San Martín de Viale
Synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats.
November 1990, Cancer letters,
R Wainstok de Calmanovici, and S C Billi, and C A Aldonatti, and L C San Martín de Viale
Influence of (+)-propoxyphene on the hexachlorobenzene-induced porphyria of rats.
January 1985, Arzneimittel-Forschung,
R Wainstok de Calmanovici, and S C Billi, and C A Aldonatti, and L C San Martín de Viale
Mechanism of hexachlorobenzene-induced porphyria in rats. Effect of phenobarbitone pretreatment.
March 1984, The Biochemical journal,
R Wainstok de Calmanovici, and S C Billi, and C A Aldonatti, and L C San Martín de Viale
The effect of bleeding and iron administration on the development of hexachlorobenzene-induced rat porphyria.
January 1980, The International journal of biochemistry,
R Wainstok de Calmanovici, and S C Billi, and C A Aldonatti, and L C San Martín de Viale
[Effect of silymarin and (+)-cyanidanol-3 on hexachlorobenzene(HCB)-induced porphyria in rats].
December 1982, Zeitschrift fur Gastroenterologie,
R Wainstok de Calmanovici, and S C Billi, and C A Aldonatti, and L C San Martín de Viale
The effect of iron overload on the mitochondrial porphyrin level in the hexachlorobenzene induced experimental porphyria.
February 1988, Biochemical and biophysical research communications,
R Wainstok de Calmanovici, and S C Billi, and C A Aldonatti, and L C San Martín de Viale
Influence of N-acetylcysteine on the hexachlorobenzene induced porphyria in rats.
January 1985, Arzneimittel-Forschung,
R Wainstok de Calmanovici, and S C Billi, and C A Aldonatti, and L C San Martín de Viale
The effect of iron overload on the development of hexachlorobenzene (HCB) porphyria.
September 1971, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
R Wainstok de Calmanovici, and S C Billi, and C A Aldonatti, and L C San Martín de Viale
Hexachlorobenzene porphyria and hexachlorobenzene catabolism in rats.
February 1978, Biochemical and biophysical research communications,
Copied contents to your clipboard!