Long-term effects of multiple concussions on prefrontal cortex oxygenation during repeated squat-stands in retired contact sport athletes. 2022

Luke W Sirant, and Jyotpal Singh, and Steve Martin, and Catherine A Gaul, and Lynneth Stuart-Hill, and Darren G Candow, and Cameron Mang, and J Patrick Neary
Faculty of Kinesiology and Health Studies, University of Regina, Regina, SK, Canada.

This study investigated the long-term effects of multiple concussions on prefrontal cortex oxygenation using near-infrared spectroscopy (NIRS) during a squat-stand maneuver that activated dynamic cerebral autoregulation. Active male retired contact sport athletes with a history of 3+ concussions (mTBI; n = 55), and active retired athletes with no concussion history (CTRL; n = 29) were recruited. Participants completed a 5-min squat-stand maneuve (10-s squat, 10-s stand, 0.05 Hz; 15 times). Oxygenated (O2Hb), deoxygenated (HHb), total (tHb) hemoglobin, and hemoglobin difference (HbDiff) were analyzed through the change in maximal and minimal values during the test (∆MAX), Z-scores, and standard deviations. mTBI group showed left prefrontal cortex O2Hb ∆MAX (p = 0.046) and HbDiff ∆MAX (p = 0.018) were significantly higher. Within-group analyses showed significantly higher left HHb ∆MAX (p = 0.003) and lower left HbDiff Z-scores (p = 0.010) only in the mTBI group. The CTRL group demonstrated significantly lower left HbDiff SD (p = 0.039), tHb Z-scores (p = 0.030), and HbDiff ∆MAX (p = 0.037) compared to right prefrontal cortex response. These preliminary results suggest changes in prefrontal cortex oxygenation potentially affecting the brain's ability to adapt to changing cerebral perfusion pressure after multiple previous concussions.

UI MeSH Term Description Entries
D008297 Male Males
D001924 Brain Concussion A nonspecific term used to describe transient alterations or loss of consciousness following closed head injuries. The duration of UNCONSCIOUSNESS generally lasts a few seconds, but may persist for several hours. Concussions may be classified as mild, intermediate, and severe. Prolonged periods of unconsciousness (often defined as greater than 6 hours in duration) may be referred to as post-traumatic coma (COMA, POST-HEAD INJURY). (From Rowland, Merritt's Textbook of Neurology, 9th ed, p418) Cerebral Concussion,Commotio Cerebri,Concussion, Intermediate,Concussion, Mild,Concussion, Severe,Mild Traumatic Brain Injury,Brain Concussions,Cerebral Concussions,Concussion, Brain,Concussion, Cerebral,Intermediate Concussion,Intermediate Concussions,Mild Concussion,Mild Concussions,Severe Concussion,Severe Concussions
D006454 Hemoglobins The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements. Eryhem,Ferrous Hemoglobin,Hemoglobin,Hemoglobin, Ferrous
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D017397 Prefrontal Cortex The rostral part of the frontal lobe, bounded by the inferior precentral fissure in humans, which receives projection fibers from the MEDIODORSAL NUCLEUS OF THE THALAMUS. The prefrontal cortex receives afferent fibers from numerous structures of the DIENCEPHALON; MESENCEPHALON; and LIMBIC SYSTEM as well as cortical afferents of visual, auditory, and somatic origin. Anterior Prefrontal Cortex,Brodmann Area 10,Brodmann Area 11,Brodmann Area 12,Brodmann Area 47,Brodmann's Area 10,Brodmann's Area 11,Brodmann's Area 12,Brodmann's Area 47,Pars Orbitalis,Frontal Sulcus,Gyrus Frontalis Inferior,Gyrus Frontalis Superior,Gyrus Orbitalis,Gyrus Rectus,Inferior Frontal Gyrus,Lateral Orbitofrontal Cortex,Marginal Gyrus,Medial Frontal Gyrus,Olfactory Sulci,Orbital Area,Orbital Cortex,Orbital Gyri,Orbitofrontal Cortex,Orbitofrontal Gyri,Orbitofrontal Gyrus,Orbitofrontal Region,Rectal Gyrus,Rectus Gyrus,Straight Gyrus,Subcallosal Area,Superior Frontal Convolution,Superior Frontal Gyrus,Ventral Medial Prefrontal Cortex,Ventromedial Prefrontal Cortex,Anterior Prefrontal Cortices,Area 10, Brodmann,Area 10, Brodmann's,Area 11, Brodmann,Area 11, Brodmann's,Area 12, Brodmann,Area 12, Brodmann's,Area 47, Brodmann,Area 47, Brodmann's,Area, Orbital,Area, Subcallosal,Brodmanns Area 10,Brodmanns Area 11,Brodmanns Area 12,Brodmanns Area 47,Convolution, Superior Frontal,Convolutions, Superior Frontal,Cortex, Anterior Prefrontal,Cortex, Lateral Orbitofrontal,Cortex, Orbital,Cortex, Orbitofrontal,Cortex, Prefrontal,Cortex, Ventromedial Prefrontal,Cortices, Ventromedial Prefrontal,Frontal Convolution, Superior,Frontal Gyrus, Inferior,Frontal Gyrus, Medial,Frontal Gyrus, Superior,Frontalis Superior, Gyrus,Gyrus, Inferior Frontal,Gyrus, Marginal,Gyrus, Medial Frontal,Gyrus, Orbital,Gyrus, Orbitofrontal,Gyrus, Rectal,Gyrus, Rectus,Gyrus, Straight,Gyrus, Superior Frontal,Inferior, Gyrus Frontalis,Lateral Orbitofrontal Cortices,Olfactory Sulcus,Orbital Areas,Orbital Cortices,Orbital Gyrus,Orbitalis, Pars,Orbitofrontal Cortex, Lateral,Orbitofrontal Cortices,Orbitofrontal Cortices, Lateral,Orbitofrontal Regions,Prefrontal Cortex, Anterior,Prefrontal Cortex, Ventromedial,Prefrontal Cortices, Anterior,Region, Orbitofrontal,Subcallosal Areas,Sulcus, Frontal,Superior Frontal Convolutions,Superior, Gyrus Frontalis,Ventromedial Prefrontal Cortices
D056352 Athletes Individuals who have developed skills, physical stamina and strength or participants in SPORTS or other physical activities. College Athletes,Elite Athletes,Professional Athletes,Athlete,Athlete, College,Athlete, Elite,Athlete, Professional,Athletes, College,Athletes, Elite,Athletes, Professional,College Athlete,Elite Athlete,Professional Athlete
D019265 Spectroscopy, Near-Infrared A noninvasive technique that uses the differential absorption properties of hemoglobin and myoglobin to evaluate tissue oxygenation and indirectly can measure regional hemodynamics and blood flow. Near-infrared light (NIR) can propagate through tissues and at particular wavelengths is differentially absorbed by oxygenated vs. deoxygenated forms of hemoglobin and myoglobin. Illumination of intact tissue with NIR allows qualitative assessment of changes in the tissue concentration of these molecules. The analysis is also used to determine body composition. NIR Spectroscopy,Spectrometry, Near-Infrared,NIR Spectroscopies,Near-Infrared Spectrometries,Near-Infrared Spectrometry,Near-Infrared Spectroscopies,Near-Infrared Spectroscopy,Spectrometries, Near-Infrared,Spectrometry, Near Infrared,Spectroscopies, NIR,Spectroscopies, Near-Infrared,Spectroscopy, NIR,Spectroscopy, Near Infrared

Related Publications

Luke W Sirant, and Jyotpal Singh, and Steve Martin, and Catherine A Gaul, and Lynneth Stuart-Hill, and Darren G Candow, and Cameron Mang, and J Patrick Neary
January 2021, Frontiers in neurology,
Luke W Sirant, and Jyotpal Singh, and Steve Martin, and Catherine A Gaul, and Lynneth Stuart-Hill, and Darren G Candow, and Cameron Mang, and J Patrick Neary
October 2018, International journal of psychophysiology : official journal of the International Organization of Psychophysiology,
Luke W Sirant, and Jyotpal Singh, and Steve Martin, and Catherine A Gaul, and Lynneth Stuart-Hill, and Darren G Candow, and Cameron Mang, and J Patrick Neary
April 2013, Journal of sport & exercise psychology,
Luke W Sirant, and Jyotpal Singh, and Steve Martin, and Catherine A Gaul, and Lynneth Stuart-Hill, and Darren G Candow, and Cameron Mang, and J Patrick Neary
June 2007, Brain injury,
Luke W Sirant, and Jyotpal Singh, and Steve Martin, and Catherine A Gaul, and Lynneth Stuart-Hill, and Darren G Candow, and Cameron Mang, and J Patrick Neary
January 2018, The Journal of head trauma rehabilitation,
Luke W Sirant, and Jyotpal Singh, and Steve Martin, and Catherine A Gaul, and Lynneth Stuart-Hill, and Darren G Candow, and Cameron Mang, and J Patrick Neary
January 2017, The health care manager,
Luke W Sirant, and Jyotpal Singh, and Steve Martin, and Catherine A Gaul, and Lynneth Stuart-Hill, and Darren G Candow, and Cameron Mang, and J Patrick Neary
January 2018, The Journal of head trauma rehabilitation,
Luke W Sirant, and Jyotpal Singh, and Steve Martin, and Catherine A Gaul, and Lynneth Stuart-Hill, and Darren G Candow, and Cameron Mang, and J Patrick Neary
August 2019, Brain sciences,
Luke W Sirant, and Jyotpal Singh, and Steve Martin, and Catherine A Gaul, and Lynneth Stuart-Hill, and Darren G Candow, and Cameron Mang, and J Patrick Neary
January 2020, Frontiers in human neuroscience,
Luke W Sirant, and Jyotpal Singh, and Steve Martin, and Catherine A Gaul, and Lynneth Stuart-Hill, and Darren G Candow, and Cameron Mang, and J Patrick Neary
February 2020, Journal of athletic training,
Copied contents to your clipboard!