Biomaterial Database

Subcutaneous fat necrosis of the newborn with emphasis on ultrastructural studies. 1987

M Balázs

The morphologic examination of neonatal subcutaneous fat necrosis is reported. Subcutaneous nodules after prolonged labor and asphyxia appeared in the skin of the back and neck. Biopsy was performed at 16 days. The infants' general state did not change and the nodules spontaneously regressed. Light microscopically focal necroses of the subcutaneous adipose tissue were present, with granulation tissue. Electron microscopy revealed complex material replacing the necrotic fat cells. Two types of crystals could be observed: short, rectangular ones irregularly arranged and long, needle-shaped ones, parallel or radial in arrangement. The dissolved lipid crystals were surrounded by membranes that probably arose from the necrotic fat cells. The crystals passed the cytoplasm membrane of the macrophages. Giant cells arose from macrophages, partly by fusion of the cells and partly by amitosis.

UI	MeSH Term	Description	Entries
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008854	Microscopy, Electron	Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.	Electron Microscopy
D009336	Necrosis	The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
D005218	Fat Necrosis	A condition in which the death of adipose tissue results in neutral fats being split into fatty acids and glycerol.	Steatonecrosis,Fat Necroses,Necrosis, Fat,Steatonecroses
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000273	Adipose Tissue	Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.	Fatty Tissue,Body Fat,Fat Pad,Fat Pads,Pad, Fat,Pads, Fat,Tissue, Adipose,Tissue, Fatty