Comparative effects of tocopherol and ubiquinol on arsenic induced nephrotoxicity in sprague dawley rats. 2022

Urfa Zaryab Mir, and Amir Rashid, and Palvasha Waheed, and Javad Yousaf, and Amaidah Mir
Department of Biochemistry and Molecular Biology Army Medical College, National University of Medical Sciences (NUMS) Rawalpindi, Pakistan.

Millions of the people worldwide are drinking arsenic polluted water. The need of time is to find out the mitigation strategies to cope with this issue. To evaluate the effects of tocopherol and ubiquinol individually and collectively on arsenic induced nephrotoxicity in Sprague Dawley rats. 150 Sprague Dawley rats were divided into 5 groups randomly. Animals of group I were provided with distilled water and sterile diet pellets. All other groups were given arsenic contaminated water (5mg/L) ad libitum. Moreover, ubiquinol and tocopherol (250mg/kg each) were given to group III and IV rats respectively. Whereas, both tocopherol and ubiquinol (125mg/kg each) was given to rats of group V. After 2 weeks of intervention period, serum RFTs were evaluated on micro lab. After exposure to arsenic, animals of group II showed a significant (p<0.01) elevation of serum RFTs. Treatment with ubiquinol in group III animals and tocopherol in group IV animals reduced the levels (p<0.01) of serum RFTs in these groups. Whereas, the combined effects of both these antioxidants reversed these changes to normal values (p>0.05). Both tocopherol and ubiquinol (synergistically) are more efficient in minimizing the nephrotoxicity induced by arsenic.

UI MeSH Term Description Entries
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000975 Antioxidants Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. Anti-Oxidant,Antioxidant,Antioxidant Activity,Endogenous Antioxidant,Endogenous Antioxidants,Anti-Oxidant Effect,Anti-Oxidant Effects,Anti-Oxidants,Antioxidant Effect,Antioxidant Effects,Activity, Antioxidant,Anti Oxidant,Anti Oxidant Effect,Anti Oxidant Effects,Anti Oxidants,Antioxidant, Endogenous,Antioxidants, Endogenous
D001151 Arsenic A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed) Arsenic-75,Arsenic 75
D014451 Ubiquinone A lipid-soluble benzoquinone which is involved in ELECTRON TRANSPORT in mitochondrial preparations. The compound occurs in the majority of aerobic organisms, from bacteria to higher plants and animals. Coenzyme Q
D014810 Vitamin E A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.
D014867 Water A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Hydrogen Oxide
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D024505 Tocopherols A collective name for a group of closely related lipids that contain substitutions on the 2H-1-benzopyran-6-ol nucleus and a long hydrocarbon chain of isoprenoid units. They are antioxidants by virtue of the phenolic hydrogen. Tocopherols react with the most reactive form of oxygen and protect unsaturated fatty acids from oxidation. Tocopherol,Abortosan,Antioxidans E-Hevert,Aquasol E,Auxina E,Bio E,Biopto-E,Biosan,Bioweyxin,Dal-E,Davitamon,Dermorelle,Detulin,E Vitamin E,E-Mulsin,E-Vicotrat,E-Vitamin-Ratiopharm,E-ferol,EUNOVA Vitamin E,Ecoro,Elex Verla,Embial,Ephynal,Eplonat,Equivit E,Eusovit,Evion,Hydrovit E,Lasar,Malton E,Micorvit E,Mowivit Vitamin E,Puncto E,Richtavit E,Sanavitan S,Snow-E Muscle, Energy & Feritility,Spondyvit,Tocolion,Tocopa,Tocopharm,Tocopherol Bayer,Tocovital,Togasan Vitamin E,Unique E,Uno-Vit,Vibolex,Vit E hydrosol,Vit. E Stada,Vita-E,Vita-Plus E,Vitagutt Vitamin E,Vitamin E AL,Vitamin E Natur,Vitamin E Sanum,Vitamin E Suspension,Vitamin E-mp,Vitamin-E Dragees,Vitamin-E EVI-MIRALE,Vitamine E GNR,Vitazell,Dal E,E Mulsin,E Vicotrat,Uno Vit,UnoVit,Vita E,Vita Plus E,VitaE,VitaPlus E,Vitamin E Dragees,Vitamin E EVI MIRALE,Vitamin E mp,Vitamin E, Mowivit,Vitamin E, Togasan,Vitamin E, Vitagutt,Vitamin Emp,VitaminE EVIMIRALE

Related Publications

Urfa Zaryab Mir, and Amir Rashid, and Palvasha Waheed, and Javad Yousaf, and Amaidah Mir
May 2015, Journal of medicinal food,
Urfa Zaryab Mir, and Amir Rashid, and Palvasha Waheed, and Javad Yousaf, and Amaidah Mir
April 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Urfa Zaryab Mir, and Amir Rashid, and Palvasha Waheed, and Javad Yousaf, and Amaidah Mir
November 2012, Microchemical journal : devoted to the application of microtechniques in all branches of science,
Urfa Zaryab Mir, and Amir Rashid, and Palvasha Waheed, and Javad Yousaf, and Amaidah Mir
August 2003, Urology,
Urfa Zaryab Mir, and Amir Rashid, and Palvasha Waheed, and Javad Yousaf, and Amaidah Mir
January 2011, Journal of Ayub Medical College, Abbottabad : JAMC,
Urfa Zaryab Mir, and Amir Rashid, and Palvasha Waheed, and Javad Yousaf, and Amaidah Mir
August 1998, Nephron,
Urfa Zaryab Mir, and Amir Rashid, and Palvasha Waheed, and Javad Yousaf, and Amaidah Mir
January 2018, Journal of toxicology and environmental health. Part A,
Urfa Zaryab Mir, and Amir Rashid, and Palvasha Waheed, and Javad Yousaf, and Amaidah Mir
February 1986, Toxicology letters,
Urfa Zaryab Mir, and Amir Rashid, and Palvasha Waheed, and Javad Yousaf, and Amaidah Mir
June 1986, Toxicology letters,
Urfa Zaryab Mir, and Amir Rashid, and Palvasha Waheed, and Javad Yousaf, and Amaidah Mir
November 2013, Environmental toxicology and pharmacology,
Copied contents to your clipboard!