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Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides. 2022
Denis V Sudarikov, and
Yulia V Gyrdymova, and
Alexander V Borisov, and
Julia M Lukiyanova, and
Roman V Rumyantcev, and
Oksana G Shevchenko, and
Diana R Baidamshina, and
Nargiza D Zakarova, and
Airat R Kayumov, and
Ekaterina O Sinegubova, and
Alexandrina S Volobueva, and
Vladimir V Zarubaev, and
Svetlana A Rubtsova
Institute of Chemistry, FRC "Komi Scientific Centre", Ural Branch of the Russian Academy of Sciences, Pervomayskaya St. 48, 167000 Syktyvkar, Komi Republic, Russia.
New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time in 48-88% yields. Hydrolysis of disulfides with fragments of methyl esters of 2-mercaptonicotinic acid was carried out in 73-95% yields. The obtained compounds were evaluated for antioxidant, antibacterial, antifungal activity, cytotoxicity and mutagenicity.
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