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Catecholamine and serotonin in the focus tissues of 12 intractable epileptic patients who underwent surgery were analysed by high performance liquid chromatography with electrochemical detection, and it was found that dopamine contents in epileptic foci were clearly lower than in surrounding tissue in 7 of the 12 epileptics examined. In the other 5 patients, dopamine levels were much lower than in non-convulsive neuropathic patients.
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