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The effect of prostacyclin on platelet aggregation and adhesion was investigated in everted pieces of rabbit abdominal aorta, from which the endothelium had previously been removed. Citrated human blood, to which different, concentrations of prostacyclin (0.1-100 ng/ml) were added, was perfused through the vessels, after which sections were examined and evaluated by light microscopy. Prostacyclin inhibited thrombus formation at concentrations greater than 0.1 ng/ml, whereas 20 ng/ml were required to reduce the amount of adhesion to the subendothelial surface. Thus prostacyclin prevents thrombus formation at much lower concentrations than are needed to inhibit platelet-vessel wall interaction.
E A Higgs, and
S Moncada, and
J R Vane, and
J P Caen, and
H Michel, and
G Tobelem
February 1979,
Blood,
E A Higgs, and
S Moncada, and
J R Vane, and
J P Caen, and
H Michel, and
G Tobelem
January 1979,
Haemostasis,
E A Higgs, and
S Moncada, and
J R Vane, and
J P Caen, and
H Michel, and
G Tobelem
September 1980,
Thrombosis research,
E A Higgs, and
S Moncada, and
J R Vane, and
J P Caen, and
H Michel, and
G Tobelem
January 1988,
Arteriosclerosis (Dallas, Tex.),
E A Higgs, and
S Moncada, and
J R Vane, and
J P Caen, and
H Michel, and
G Tobelem
July 1979,
Pharmacological research communications,
E A Higgs, and
S Moncada, and
J R Vane, and
J P Caen, and
H Michel, and
G Tobelem
January 1999,
Methods in molecular biology (Clifton, N.J.),
E A Higgs, and
S Moncada, and
J R Vane, and
J P Caen, and
H Michel, and
G Tobelem
September 1983,
Circulation research,
E A Higgs, and
S Moncada, and
J R Vane, and
J P Caen, and
H Michel, and
G Tobelem
January 1981,
Thrombosis research,
E A Higgs, and
S Moncada, and
J R Vane, and
J P Caen, and
H Michel, and
G Tobelem
March 1983,
Prostaglandins,
E A Higgs, and
S Moncada, and
J R Vane, and
J P Caen, and
H Michel, and
G Tobelem
April 1984,
Klinika oczna,
