| D007093 |
Imidazoles |
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES). |
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| D011720 |
Pyrazoles |
Azoles of two nitrogens at the 1,2 positions, next to each other, in contrast with IMIDAZOLES in which they are at the 1,3 positions. |
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| D002470 |
Cell Survival |
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. |
Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell |
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| D004261 |
DNA Replication |
The process by which a DNA molecule is duplicated. |
Autonomous Replication,Replication, Autonomous,Autonomous Replications,DNA Replications,Replication, DNA,Replications, Autonomous,Replications, DNA |
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| D000075686 |
COP9 Signalosome Complex |
A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light. |
COP9 Signalosome (CSN),COP9 Signalosome Subunit 1,COP9 Signalosome Subunit 2,COP9 Signalosome Subunit 3,COP9 Signalosome Subunit 4,COP9 Signalosome Subunit 5,COP9 Signalosome Subunit 6,COP9 Signalosome Subunit 7A,COP9 Signalosome Subunit 7B,COP9 Signalosome Subunit 8,COP9 Signalsome,Constitutive Photomorphogenesis 9 Signalosome,Constitutive Photomorphogenesis 9 Signalsome,FUSCA Protein 11,G Protein Pathway Suppressor 1,Sgn3,Signalosome Subunit 3,Signalosome Complex, COP9,Signalsome, COP9,Subunit 3, Signalosome |
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| D000075687 |
NEDD8 Protein |
A ubiquitin-like protein that functions in CELL CYCLE regulation and embryogenesis. It is attached covalently to its substrates following activation by the UBIQUITIN-ACTIVATING ENZYME E1-UBA3 enzyme complex. NEDD8 attaches to CULLINS, activating their E3 UBIQUITIN LIGASE activity, to promote polyubiquitination and degradation of CYCLINS and regulatory proteins |
NEDD-8 Protein,Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8,Ubiquitin-like Protein NEDD8,NEDD 8 Protein,NEDD8, Ubiquitin-like Protein,Neural Precursor Cell Expressed Developmentally Down Regulated Protein 8,Ubiquitin like Protein NEDD8 |
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| D001381 |
Azepines |
Seven membered heterocyclic rings containing a NITROGEN atom. |
Hexamethyleneimines |
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| D044767 |
Ubiquitin-Protein Ligases |
A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes. |
Ubiquitin-Protein Ligase,E3 Ligase,E3 Ubiquitin Ligase,Ubiquitin Ligase E3,Ubiquitin-Protein Ligase E3,Ligase E3, Ubiquitin,Ligase E3, Ubiquitin-Protein,Ligase, E3,Ligase, E3 Ubiquitin,Ligase, Ubiquitin-Protein,Ligases, Ubiquitin-Protein,Ubiquitin Ligase, E3,Ubiquitin Protein Ligase,Ubiquitin Protein Ligase E3,Ubiquitin Protein Ligases |
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| D044842 |
Cullin Proteins |
A family of structurally related proteins that were originally discovered for their role in cell-cycle regulation in CAENORHABDITIS ELEGANS. They play important roles in regulation of the CELL CYCLE and as components of UBIQUITIN-PROTEIN LIGASES. |
Cullin,Cullin Domain Protein,Cullin Domain Proteins,Cullin Protein,Cullins |
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