Biomaterial Database

Experimental aflatoxicosis in hybro-type chicks: sequential changes in growth and serum constituents and histopathological changes. 1987

R Dafalla, and A Yagi, and S E Adam

The effects of aflatoxin B1 on Hybro-type chicks were determined. Seven day-old chicks of both sexes were fed a diet containing aflatoxin at 0.5 ppm for 4 weeks. When compared to the controls, body weights and efficiency of feed utilization were depressed in the aflatoxin-fed group. The activities of serum sorbitol dehydrogenase (SDH) and glutamic dehydrogenase (GDH) and concentrations of potassium were significantly elevated, and total protein and calcium levels were decreased in aflatoxin-fed chicks. There were no consistent differences in the concentrations of other serum constituents between the controls and test birds. Histopathological examinations of liver and kidney sections revealed typical lesions of aflatoxicosis. In the kidney, recovery was slow as indicated by the presence of vacuolation and necrosis of the cells of many renal convoluted tubules 3 weeks after withdrawal of the experimental ration.

UI	MeSH Term	Description	Entries
D007064	L-Iditol 2-Dehydrogenase	An alcohol oxidoreductase which catalyzes the oxidation of L-iditol to L-sorbose in the presence of NAD. It also acts on D-glucitol to form D-fructose. It also acts on other closely related sugar alcohols to form the corresponding sugar. EC 1.1.1.14	Iditol Dehydrogenase,Sorbitol Dehydrogenase,Polyol Dehydrogenase,2-Dehydrogenase, L-Iditol,Dehydrogenase, Iditol,Dehydrogenase, Polyol,Dehydrogenase, Sorbitol,L Iditol 2 Dehydrogenase
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D011201	Poultry Diseases	Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.	Disease, Poultry,Diseases, Poultry,Poultry Disease
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D005260	Female		Females
D005516	Food Microbiology	The presence of bacteria, viruses, and fungi in food and food products. This term is not restricted to pathogenic organisms: the presence of various non-pathogenic bacteria and fungi in cheeses and wines, for example, is included in this concept.	Microbiology, Food
D005969	Glutamate Dehydrogenase	An enzyme that catalyzes the conversion of L-glutamate and water to 2-oxoglutarate and NH3 in the presence of NAD+. (From Enzyme Nomenclature, 1992) EC 1.4.1.2.	Dehydrogenase, Glutamate
D000348	Aflatoxins	Furano-furano-benzopyrans that are produced by ASPERGILLUS from STERIGMATOCYSTIN. They are structurally related to COUMARINS and easily oxidized to an epoxide form to become ALKYLATING AGENTS. Members of the group include AFLATOXIN B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; AFLATOXIN M1; and aflatoxin M2.	Aflatoxin
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia