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Ethical considerations for precision psychiatry: A roadmap for research and clinical practice. 2022
Paolo Fusar-Poli, and
Mirko Manchia, and
Nikolaos Koutsouleris, and
David Leslie, and
Christiane Woopen, and
Monica E Calkins, and
Michael Dunn, and
Christophe Le Tourneau, and
Miia Mannikko, and
Tineke Mollema, and
Dominic Oliver, and
Marcella Rietschel, and
Eva Z Reininghaus, and
Alessio Squassina, and
Lucia Valmaggia, and
Lars Vedel Kessing, and
Eduard Vieta, and
Christoph U Correll, and
Celso Arango, and
Ole A Andreassen, and
Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; South London and Maudsley NHS Foundation Trust, London, UK; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. Electronic address: paolo.fusar-poli@kcl.ac.uk.
Precision psychiatry is an emerging field with transformative opportunities for mental health. However, the use of clinical prediction models carries unprecedented ethical challenges, which must be addressed before accessing the potential benefits of precision psychiatry. This critical review covers multidisciplinary areas, including psychiatry, ethics, statistics and machine-learning, healthcare and academia, as well as input from people with lived experience of mental disorders, their family, and carers. We aimed to identify core ethical considerations for precision psychiatry and mitigate concerns by designing a roadmap for research and clinical practice. We identified priorities: learning from somatic medicine; identifying precision psychiatry use cases; enhancing transparency and generalizability; fostering implementation; promoting mental health literacy; communicating risk estimates; data protection and privacy; and fostering the equitable distribution of mental health care. We hope this blueprint will advance research and practice and enable people with mental health problems to benefit from precision psychiatry.
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