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Concentrations of unconjugated and conjugated 2-hydroxyoestrogens and their 2-methylethers were determined by radioimmunoassay in serum obtained from the umbilical artery, umbilical vein, retroplacental space, and maternal peripheral vein at the time of delivery. The concentrations of unconjugated 2-hydroxyoestrogens and 2-methoxyoestrogens were found to be significantly higher in the post-placental vessels than in the pre-placental vessels. On the basis of the concentrations measured it was estimated that the placenta secretes about 1.4 nmol/min 2-hydroxyoestrogens and about 1.7 nmol/min of 2-methoxyoestrogens. The present in vivo findings confirm the placental 2-hydroxylase- and catechol-O-methyl-transferase activities previously demonstrated in vitro.
F D Berg, and
E Kuss
January 1953,
Acta endocrinologica. Supplementum,
F D Berg, and
E Kuss
February 1985,
Biochemical and biophysical research communications,
F D Berg, and
E Kuss
July 2019,
Nature communications,
F D Berg, and
E Kuss
June 1970,
The Biochemical journal,
F D Berg, and
E Kuss
October 1990,
The Journal of endocrinology,
F D Berg, and
E Kuss
August 1972,
Biochemical pharmacology,
F D Berg, and
E Kuss
February 2019,
Genes,
F D Berg, and
E Kuss
March 1965,
Journal of medicinal chemistry,
F D Berg, and
E Kuss
September 1986,
Naunyn-Schmiedeberg's archives of pharmacology,
