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Hepatocellular Carcinoma Rupture after Introducing Lenvatinib: An Autopsy Case Report. 2023
Risako Kohya, and
Ryo Sugiura, and
Yoshiya Yamamoto, and
Hirohito Naruse, and
Kazuteru Hatanaka, and
Kenji Kinoshita, and
Satoshi Abiko, and
Shuichi Miyamoto, and
Kazuharu Suzuki, and
Hanae Kushibiki, and
Satoru Munakata, and
Norihiko Shimoyama
Department of Gastroenterology and Hepatology, Hakodate Municipal Hospital, Japan.
Hepatocellular carcinoma (HCC) hemorrhaging/rupture is a rare adverse effect of lenvatinib, and only limited pathological examinations have been reported. This report presents the case of a 69-year-old man who suffered from cardiac arrest and died 7 days after starting lenvatinib treatment for HCC, with an autopsy subsequently performed. Crack and coagulated blood were observed in the largest tumor. Pathologically, the hemorrhaging area was scattered in nearly all of the HCC lesions, regardless of tumor differentiation. This pathological feature is unusual in normal HCC. Thus, it is believed to have been the effect of lenvatinib.
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