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The relationships between immune reactivity after blood transfusions, subsequent kidney allograft survival, and donor selection were studied in dogs. Animals with a high as well as low serological immune reactivity toward antigens contained in blood transfusion were observed. Genetic control of this reactivity or a linkage of this property to DLA, sex, or red blood cell markers inheritance was not apparent in the four beagle families studied. The two recipients with the lowest immune reactivity scores were also found to be the longest survivors after a DLA-mismatched kidney graft. Seven other recipients with higher scores rejected their DLA-mismatched kidneys as rapidly as did untransfused animals. Kidney graft survival was decreased in some recipients of DLA-identical kidneys (n = 5), presumably through sensitization for minor histocompatibility antigens. A normal or an increased survival time of DLA-identical kidneys was found in the remaining animals (n = 6). The majority of these recipients appeared to have a higher than average reactivity in two-stage microcytotoxicity testing. This might have been attributable to the presence of enhancing antibodies. Further studies in preclinical animal models are needed to define the optimal transfusion policy for human patients awaiting a kidney graft.
R W Bull, and
H M Vriesendorp, and
H Obertop, and
A B Bijnen, and
J Jeekel, and
J J de Gruijl, and
D L Westbroek
April 1982,
Transplantation,
R W Bull, and
H M Vriesendorp, and
H Obertop, and
A B Bijnen, and
J Jeekel, and
J J de Gruijl, and
D L Westbroek
March 1979,
Transplantation proceedings,
R W Bull, and
H M Vriesendorp, and
H Obertop, and
A B Bijnen, and
J Jeekel, and
J J de Gruijl, and
D L Westbroek
January 1977,
Scandinavian journal of urology and nephrology. Supplementum,
R W Bull, and
H M Vriesendorp, and
H Obertop, and
A B Bijnen, and
J Jeekel, and
J J de Gruijl, and
D L Westbroek
March 1979,
Transplantation proceedings,
R W Bull, and
H M Vriesendorp, and
H Obertop, and
A B Bijnen, and
J Jeekel, and
J J de Gruijl, and
D L Westbroek
August 1974,
Surgery, gynecology & obstetrics,
R W Bull, and
H M Vriesendorp, and
H Obertop, and
A B Bijnen, and
J Jeekel, and
J J de Gruijl, and
D L Westbroek
October 1981,
The Journal of surgical research,
R W Bull, and
H M Vriesendorp, and
H Obertop, and
A B Bijnen, and
J Jeekel, and
J J de Gruijl, and
D L Westbroek
October 1978,
Transplantation,
R W Bull, and
H M Vriesendorp, and
H Obertop, and
A B Bijnen, and
J Jeekel, and
J J de Gruijl, and
D L Westbroek
April 1978,
British medical journal,
R W Bull, and
H M Vriesendorp, and
H Obertop, and
A B Bijnen, and
J Jeekel, and
J J de Gruijl, and
D L Westbroek
June 1982,
Transplantation proceedings,
R W Bull, and
H M Vriesendorp, and
H Obertop, and
A B Bijnen, and
J Jeekel, and
J J de Gruijl, and
D L Westbroek
January 1978,
Lancet (London, England),
