Human umbilical cord blood mononuclear cells transplantation for perinatal brain injury. 2022

Yufeng Xi, and Guang Yue, and Shuqiang Gao, and Rong Ju, and Yujia Wang
Department of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.

Perinatal brain injury is a leading cause of death and disability in children. Hypoxic-ischemic encephalopathy in full term infants, and white matter injury in premature infants are most known brain injury in perinatal period. Human umbilical cord blood mononuclear cells contain hematopoietic stem cells, mesenchymal stem cells, endothelial progenitor cells, lymphocytes, monocytes, and so on. Human umbilical cord blood mononuclear cells have many biological functions, such as nerve and vascular regeneration, anti-apoptosis, anti-inflammation, and immune regulation. Human umbilical cord blood mononuclear cells transplantation has achieved significant efficacy and safety in animal and clinical trials for the treatment of perinatal brain injury. We will review human umbilical cord blood mononuclear cells transplantation for perinatal brain injury in this review.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D001930 Brain Injuries Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits. Brain Lacerations,Acute Brain Injuries,Brain Injuries, Acute,Brain Injuries, Focal,Focal Brain Injuries,Injuries, Acute Brain,Injuries, Brain,Acute Brain Injury,Brain Injury,Brain Injury, Acute,Brain Injury, Focal,Brain Laceration,Focal Brain Injury,Injuries, Focal Brain,Injury, Acute Brain,Injury, Brain,Injury, Focal Brain,Laceration, Brain,Lacerations, Brain
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D005312 Fetal Blood Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery. Cord Blood,Umbilical Cord Blood,Blood, Cord,Blood, Fetal,Blood, Umbilical Cord,Bloods, Cord,Bloods, Fetal,Bloods, Umbilical Cord,Cord Blood, Umbilical,Cord Bloods,Cord Bloods, Umbilical,Fetal Bloods,Umbilical Cord Bloods
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014470 Umbilical Cord The flexible rope-like structure that connects a developing FETUS to the PLACENTA in mammals. The cord contains blood vessels which carry oxygen and nutrients from the mother to the fetus and waste products away from the fetus. Cord, Umbilical,Cords, Umbilical,Umbilical Cords
D020925 Hypoxia-Ischemia, Brain A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions. Anoxia-Ischemia, Brain,Anoxia-Ischemia, Cerebral,Anoxic-Ischemic Encephalopathy,Brain Anoxia-Ischemia,Brain Hypoxia-Ischemia,Brain Ischemia-Anoxia,Brain Ischemia-Hypoxia,Cerebral Anoxia-Ischemia,Cerebral Hypoxia-Ischemia,Cerebral Ischemia-Anoxia,Cerebral Ischemia-Hypoxia,Hypoxia-Ischemia, Cerebral,Hypoxic-Ischemic Encephalopathy,Ischemia-Anoxia, Brain,Ischemia-Anoxia, Cerebral,Ischemia-Hypoxia, Brain,Ischemia-Hypoxia, Cerebral,Ischemic-Hypoxic Encephalopathy,Encephalopathy, Anoxic-Ischemic,Encephalopathy, Hypoxic-Ischemic,Anoxia Ischemia, Brain,Anoxia Ischemia, Cerebral,Anoxia-Ischemias, Brain,Anoxia-Ischemias, Cerebral,Anoxic Ischemic Encephalopathy,Anoxic-Ischemic Encephalopathies,Brain Anoxia Ischemia,Brain Anoxia-Ischemias,Brain Hypoxia Ischemia,Brain Hypoxia-Ischemias,Brain Ischemia Anoxia,Brain Ischemia Hypoxia,Brain Ischemia-Anoxias,Brain Ischemia-Hypoxias,Cerebral Anoxia Ischemia,Cerebral Anoxia-Ischemias,Cerebral Hypoxia Ischemia,Cerebral Hypoxia-Ischemias,Cerebral Ischemia Anoxia,Cerebral Ischemia Hypoxia,Cerebral Ischemia-Anoxias,Cerebral Ischemia-Hypoxias,Encephalopathies, Anoxic-Ischemic,Encephalopathies, Hypoxic-Ischemic,Encephalopathies, Ischemic-Hypoxic,Encephalopathy, Anoxic Ischemic,Encephalopathy, Hypoxic Ischemic,Encephalopathy, Ischemic-Hypoxic,Hypoxia Ischemia, Brain,Hypoxia Ischemia, Cerebral,Hypoxia-Ischemias, Brain,Hypoxia-Ischemias, Cerebral,Hypoxic Ischemic Encephalopathy,Hypoxic-Ischemic Encephalopathies,Ischemia Anoxia, Brain,Ischemia Anoxia, Cerebral,Ischemia Hypoxia, Brain,Ischemia Hypoxia, Cerebral,Ischemia-Anoxias, Brain,Ischemia-Anoxias, Cerebral,Ischemia-Hypoxias, Brain,Ischemia-Hypoxias, Cerebral,Ischemic Hypoxic Encephalopathy,Ischemic-Hypoxic Encephalopathies
D036101 Cord Blood Stem Cell Transplantation Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS. Umbilical Cord Blood Stem Cell Transplantation,Blood Stem Cell Transplantation, Umbilical Cord,Placental Blood Stem Cell Transplantation,Stem Cell Transplantation, Cord Blood,Stem Cell Transplantation, Placental Blood

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