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The mode of action of rhizoxin (1a), a new antitumor macrolide, was investigated. Rhizoxin inhibited fusion of the male and the female pronuclei in fertilized sea urchin eggs and inhibited cilia formation in the deciliated sea urchin embryos. In vitro, polymerization of tubulin isolated from porcine brains was completely inhibited at a 1 X 10(-5) M concentration of rhizoxin, and tubulin which had been polymerized by incubation at 37 degrees C for 30 minutes was depolymerized by addition of 1 X 10(-5) M of the drug. Activity of rhizoxin against tubulin polymerization was compared with those of other anti-tubulin drugs such as colchicine, vinblastine and ansamitocin P-3. The homologues of rhizoxin, 1b-3b, also inhibited polymerization of the purified microtuble protein at almost the same extent as rhizoxin.
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T Murai, and
Y Sato, and
T Haraguchi-Hiraoka, and
H Nagano
January 1991,
The Journal of antibiotics,
M Takahashi, and
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T Murai, and
Y Sato, and
T Haraguchi-Hiraoka, and
H Nagano
March 1986,
The Journal of antibiotics,
M Takahashi, and
S Iwasaki, and
H Kobayashi, and
S Okuda, and
T Murai, and
Y Sato, and
T Haraguchi-Hiraoka, and
H Nagano
April 1984,
The Journal of antibiotics,
M Takahashi, and
S Iwasaki, and
H Kobayashi, and
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T Murai, and
Y Sato, and
T Haraguchi-Hiraoka, and
H Nagano
November 1982,
The Journal of antibiotics,
M Takahashi, and
S Iwasaki, and
H Kobayashi, and
S Okuda, and
T Murai, and
Y Sato, and
T Haraguchi-Hiraoka, and
H Nagano
January 1986,
Cancer research,
M Takahashi, and
S Iwasaki, and
H Kobayashi, and
S Okuda, and
T Murai, and
Y Sato, and
T Haraguchi-Hiraoka, and
H Nagano
April 1969,
The Journal of antibiotics,
M Takahashi, and
S Iwasaki, and
H Kobayashi, and
S Okuda, and
T Murai, and
Y Sato, and
T Haraguchi-Hiraoka, and
H Nagano
September 1968,
Journal of medicinal chemistry,
M Takahashi, and
S Iwasaki, and
H Kobayashi, and
S Okuda, and
T Murai, and
Y Sato, and
T Haraguchi-Hiraoka, and
H Nagano
November 1992,
Annals of oncology : official journal of the European Society for Medical Oncology,
M Takahashi, and
S Iwasaki, and
H Kobayashi, and
S Okuda, and
T Murai, and
Y Sato, and
T Haraguchi-Hiraoka, and
H Nagano
January 2008,
Medicinal research reviews,
M Takahashi, and
S Iwasaki, and
H Kobayashi, and
S Okuda, and
T Murai, and
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T Haraguchi-Hiraoka, and
H Nagano
April 1963,
The Journal of antibiotics. Ser. B,
