-transparent.png){kind=logo}
Two studies of the pharmacokinetics and pharmacodynamics of intravenous nifedipine infusion were performed: the first, a randomised double-blind crossover study of nifedipine and its vehicle in eight subjects, the second a dose ranging study in nine subjects. Nifedipine pharmacokinetics did not vary with dose or duration of infusion up to 8 h, and are similar to those reported for other nifedipine preparations. Nifedipine increased heart rate and forearm blood flow and decreased blood pressure after bolus injection but not during prolonged infusion. The vehicle decreased blood pressure and increased forearm blood flow after bolus injection but not during prolonged infusion. It did not affect heart rate. The vehicle's haemodynamic activity has not been previously recognised and is of potential importance in the study of this and similar preparations of calcium antagonists.
T J Walley, and
A M Heagerty, and
K L Woods, and
R F Bing, and
J E Pohl, and
D B Barnett
January 1986,
Journal of cardiovascular pharmacology,
T J Walley, and
A M Heagerty, and
K L Woods, and
R F Bing, and
J E Pohl, and
D B Barnett
September 1985,
Journal of clinical pharmacology,
T J Walley, and
A M Heagerty, and
K L Woods, and
R F Bing, and
J E Pohl, and
D B Barnett
March 1999,
European journal of clinical pharmacology,
T J Walley, and
A M Heagerty, and
K L Woods, and
R F Bing, and
J E Pohl, and
D B Barnett
April 2011,
Journal of clinical pharmacology,
T J Walley, and
A M Heagerty, and
K L Woods, and
R F Bing, and
J E Pohl, and
D B Barnett
January 1991,
European journal of drug metabolism and pharmacokinetics,
T J Walley, and
A M Heagerty, and
K L Woods, and
R F Bing, and
J E Pohl, and
D B Barnett
April 2020,
Anesthesiology,
T J Walley, and
A M Heagerty, and
K L Woods, and
R F Bing, and
J E Pohl, and
D B Barnett
January 1987,
Clinical pharmacokinetics,
T J Walley, and
A M Heagerty, and
K L Woods, and
R F Bing, and
J E Pohl, and
D B Barnett
January 1991,
Drug metabolism and disposition: the biological fate of chemicals,
T J Walley, and
A M Heagerty, and
K L Woods, and
R F Bing, and
J E Pohl, and
D B Barnett
January 1988,
Journal of cardiovascular pharmacology,
T J Walley, and
A M Heagerty, and
K L Woods, and
R F Bing, and
J E Pohl, and
D B Barnett
February 1983,
International journal of clinical pharmacology, therapy, and toxicology,
