Computation of Activating Fields for Approximation of the Orientation-Specific Neural Response to Electrical Stimulation. 2022

Conor Keogh, and Francisco Saavedra, and Brian Andrews, and James J FitzGerald

Computational methods of determining the response of neural tissue to electrical stimulation have demonstrated value for the development of novel devices and the programming of neuromodulation therapies. Detailed biophysical models are excessively computationally intensive for many applications; simple metrics to approximate activation can speed up progress in this area. The activating function provides such a useful metric. However, this measure, defined for a specific axon orientation, is not immediately applicable to computed electric fields to assess their effects. We demonstrate a method for computation of the activating function generalized to a field in order to allow rapid computation of the effects of stimulation on neural tissue while preserving information on axon orientation. Clinical Relevance- This demonstrates a useful method of approximating the effect of electrical stimulation on nervous tissue for the development of devices and the optimization of parameters for electrical neuromodulation.

UI MeSH Term Description Entries
D009417 Nerve Tissue Differentiated tissue of the central nervous system composed of NERVE CELLS, fibers, DENDRITES, and specialized supporting cells. Nervous Tissue,Nerve Tissues,Nervous Tissues,Tissue, Nerve,Tissue, Nervous,Tissues, Nerve,Tissues, Nervous
D004558 Electric Stimulation Use of electric potential or currents to elicit biological responses. Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D004560 Electricity The physical effects involving the presence of electric charges at rest and in motion.
D001369 Axons Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body. Axon

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