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Effects of varying temperature (26, 32, 38 degrees C) on age-related differences in inotropic and chronotropic sensitivities were investigated on electrically stimulated left atria and spontaneously beating right atria isolated from newborn and adult rabbits. Adult tissue had significantly greater sensitivity (low ED50) than newborn tissues to isoproterenol-induced inotropic responses at 26 and 32 degrees C (p less than 0.01), but not at 38 degrees C. The chronotropic sensitivity of adult tissues was significantly greater than the newborn at 26 degrees C (p less than 0.01), but not different at 32 or 38 degrees C. It is concluded that age-related differences in inotropic and chronotropic responses in vitro are more pronounced at low temperatures and tend to disappear at physiological temperatures.
M K Park, and
J M Johnson, and
S Hayashi
January 1979,
Comparative biochemistry and physiology. C: Comparative pharmacology,
M K Park, and
J M Johnson, and
S Hayashi
March 1976,
The Tohoku journal of experimental medicine,
M K Park, and
J M Johnson, and
S Hayashi
April 1979,
Cardiovascular research,
M K Park, and
J M Johnson, and
S Hayashi
March 1993,
Circulatory shock,
M K Park, and
J M Johnson, and
S Hayashi
January 1984,
Journal of cardiovascular pharmacology,
M K Park, and
J M Johnson, and
S Hayashi
January 1989,
Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia,
M K Park, and
J M Johnson, and
S Hayashi
November 1963,
Archives internationales de physiologie et de biochimie,
M K Park, and
J M Johnson, and
S Hayashi
June 1978,
European journal of pharmacology,
M K Park, and
J M Johnson, and
S Hayashi
August 1976,
Canadian journal of physiology and pharmacology,
M K Park, and
J M Johnson, and
S Hayashi
December 1992,
Canadian journal of physiology and pharmacology,
