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Neoagarotetraose alleviates high fat diet induced obesity via white adipocytes browning and regulation of gut microbiota. 2022

Na Zhang, and Qing Wang, and Fudi Lin, and Bingde Zheng, and Yayan Huang, and Yucheng Yang, and Changhu Xue, and Meitian Xiao, and Jing Ye
College of Chemical Engineering, Huaqiao University, Jimei Road, Jimei District, Xiamen 361021, Fujian, China; Xiamen Engineering and Technological Research Center for Comprehensive Utilization of Marine Biological Resources, Jimei Road, Jimei District, Xiamen 361021, Fujian, China. Electronic address: zhangna@hqu.edu.cn.

Obesity is nowadays a serious public health issue. Neoagarotetraose (NA4) is a marine oligosaccharide produced by the enzymatic hydrolysis of agar by β-agarase. The present study is aimed to determine the effect of NA4 on high-fat diet (HFD)-induced obesity in mice and uncover the regulating role of gut microbiota and microbial metabolites. The results showed that the intervention of NA4 significantly reduced the body weight gain, insulin resistance, hepatic adipose accumulation, serum lipid levels, oxidative damages, and inflammation responses in HFD-induced obese mice. NA4 also promoted lipolysis and browning of white adipose tissue, inhibit lipogenesis, and protect the integrity of gut barrier. Moreover, NA4 restructured the altered gut microbiota and enhanced the content of short-chain fatty acids (SCFAs) in the feces with compared with the HFD group. Cumulatively, these findings suggest that NA4 can relieve obesity by stimulating white adipose tissue browning, regulating intestinal flora, and promoting microbial metabolism.

UI MeSH Term Description Entries
D009765 Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
D009844 Oligosaccharides Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form. Oligosaccharide
D005697 Galactosides Glycosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of galactose with an alcohol to form an acetal. They include both alpha- and beta-galactosides.
D000069196 Gastrointestinal Microbiome All of the microbial organisms that naturally exist within the GASTROINTESTINAL TRACT. Enteric Bacteria,Gastric Microbiome,Gastrointestinal Flora,Gastrointestinal Microbial Community,Gastrointestinal Microbiota,Gastrointestinal Microflora,Gut Flora,Gut Microbiome,Gut Microbiota,Gut Microflora,Intestinal Flora,Intestinal Microbiome,Intestinal Microbiota,Intestinal Microflora,Bacteria, Enteric,Flora, Gastrointestinal,Flora, Gut,Flora, Intestinal,Gastric Microbiomes,Gastrointestinal Microbial Communities,Gastrointestinal Microbiomes,Gastrointestinal Microbiotas,Gut Microbiomes,Gut Microbiotas,Intestinal Microbiomes,Intestinal Microbiotas,Microbial Community, Gastrointestinal,Microbiome, Gastric,Microbiome, Gastrointestinal,Microbiome, Gut,Microbiome, Intestinal,Microbiota, Gastrointestinal,Microbiota, Gut,Microbiota, Intestinal,Microflora, Gastrointestinal,Microflora, Gut,Microflora, Intestinal
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D052438 Adipocytes, White Fat cells with light coloration and few MITOCHONDRIA. They contain a scant ring of CYTOPLASM surrounding a single large lipid droplet or vacuole. White Adipocytes,White Fat Cells,Adipocyte, White,Cell, White Fat,Cells, White Fat,Fat Cell, White,Fat Cells, White,White Adipocyte,White Fat Cell
D059305 Diet, High-Fat Consumption of excessive DIETARY FATS. Diet, High Fat,Diets, High Fat,Diets, High-Fat,High Fat Diet,High Fat Diets,High-Fat Diet,High-Fat Diets

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