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The effect of amoxicillin on galactose absorption across rat small intestine was investigated by using in vivo and in vitro techniques. Amoxicillin caused a dose-related, time-dependent, and reversible inhibition in intestinal sugar transport. Intestinal galactose transport was not affected when the drug was perfused in an adjacent loop. Also, intestinal oxygen consumption was not impaired by amoxicillin. Amoxicillin decreased the apparent affinity of galactose for the carrier system, while both its maximum absorptive capacity and the phlorhizin-insensitive component of sugar absorption remained unaltered.
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