Oral squamous cell carcinoma arising from chronic traumatic ulcers. 2023

Gerardo Gilligan, and Eduardo Piemonte, and Jerónimo Lazos, and María Celeste Simancas, and René Panico, and Saman Warnakulasuriya
Oral Medicine Department, Facultad de Odontología, Universidad Nacional de Córdoba, Haya de la Torre SN, 5000, Córdoba, Argentina. ggilligan@unc.edu.ar.

BACKGROUND A proportion of oral squamous cell carcinoma (OSCC) is preceded by oral potentially malignant disorders (OPMD), and the rest might not be associated with any well-established OPMD. Chronic traumatic ulcer (CTU) has been suggested as a lesion with potential for malignant transformation, but the evidence is inconclusive. OBJECTIVE The aim of this study was to describe clinicopathological features of non-healing CTU (NHCTU) that later developed to OSCC. METHODS A retrospective cohort study was performed of patients attending the Facultad de Odontología Universidad Nacional de Córdoba (2013-2019). The study included patients with a provisional diagnosis of CTU. CTUs without complete healing after removal of traumatic factors-non healing CTU (NHCTU)-were investigated by biopsy. A detailed description of cases where a malignancy was diagnosed is presented. RESULTS A total of 107 CTU were included. Of these, 32 CTUs were considered NHCTU and two cases showed histological features of OSCC in the background of NHCTU. In both cases, lesions were found on the lateral tongue. Both were non smoking, non alcohol drinking individuals. Absence of any well-known OPMD was also registered. CONCLUSIONS The possibility of malignant transformation in a subset of tongue NHCTU should not be underestimated. CONCLUSIONS In a subgroup of patients, NHCTU could be considered an OPMD. Although the potential malignant transformation rate is low, these conditions should be always followed up.

UI MeSH Term Description Entries
D009062 Mouth Neoplasms Tumors or cancer of the MOUTH. Cancer of Mouth,Mouth Cancer,Oral Cancer,Oral Neoplasms,Cancer of the Mouth,Neoplasms, Mouth,Neoplasms, Oral,Cancer, Mouth,Cancer, Oral,Cancers, Mouth,Cancers, Oral,Mouth Cancers,Mouth Neoplasm,Neoplasm, Mouth,Neoplasm, Oral,Oral Cancers,Oral Neoplasm
D011230 Precancerous Conditions Pathological conditions that tend eventually to become malignant. Preneoplastic Conditions,Condition, Preneoplastic,Conditions, Preneoplastic,Preneoplastic Condition,Condition, Precancerous,Conditions, Precancerous,Precancerous Condition
D002294 Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed) Carcinoma, Epidermoid,Carcinoma, Planocellular,Carcinoma, Squamous,Squamous Cell Carcinoma,Carcinomas, Epidermoid,Carcinomas, Planocellular,Carcinomas, Squamous,Carcinomas, Squamous Cell,Epidermoid Carcinoma,Epidermoid Carcinomas,Planocellular Carcinoma,Planocellular Carcinomas,Squamous Carcinoma,Squamous Carcinomas,Squamous Cell Carcinomas
D002471 Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill. Neoplastic Transformation, Cell,Neoplastic Cell Transformation,Transformation, Neoplastic Cell,Tumorigenic Transformation,Cell Neoplastic Transformation,Cell Neoplastic Transformations,Cell Transformations, Neoplastic,Neoplastic Cell Transformations,Neoplastic Transformations, Cell,Transformation, Cell Neoplastic,Transformation, Tumorigenic,Transformations, Cell Neoplastic,Transformations, Neoplastic Cell,Transformations, Tumorigenic,Tumorigenic Transformations
D006258 Head and Neck Neoplasms Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651) Cancer of Head and Neck,Head Cancer,Head Neoplasm,Head and Neck Cancer,Head and Neck Neoplasm,Neck Cancer,Neck Neoplasm,Neck Neoplasms,Neoplasms, Upper Aerodigestive Tract,UADT Neoplasm,Upper Aerodigestive Tract Neoplasm,Upper Aerodigestive Tract Neoplasms,Cancer of Head,Cancer of Neck,Cancer of the Head,Cancer of the Head and Neck,Cancer of the Neck,Head Neoplasms,Head, Neck Neoplasms,Neoplasms, Head,Neoplasms, Head and Neck,Neoplasms, Neck,UADT Neoplasms,Cancer, Head,Cancer, Neck,Cancers, Head,Cancers, Neck,Head Cancers,Neck Cancers,Neoplasm, Head,Neoplasm, Neck,Neoplasm, UADT,Neoplasms, UADT
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077195 Squamous Cell Carcinoma of Head and Neck The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer. HNSCC,Head And Neck Squamous Cell Carcinomas,Hypopharyngeal Squamous Cell Carcinoma,Laryngeal Squamous Cell Carcinoma,Oral Cavity Squamous Cell Carcinoma,Oral Squamous Cell Carcinoma,Oral Squamous Cell Carcinomas,Oral Tongue Squamous Cell Carcinoma,Oropharyngeal Squamous Cell Carcinoma,Squamous Cell Carcinoma of Larynx,Squamous Cell Carcinoma of the Larynx,Squamous Cell Carcinoma of the Mouth,Squamous Cell Carcinoma of the Nasal Cavity,Carcinoma, Squamous Cell of Head and Neck,Head and Neck Squamous Cell Carcinoma,Squamous Cell Carcinoma of the Head and Neck,Squamous Cell Carcinoma, Head And Neck
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D014456 Ulcer A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue. Ulcers

Related Publications

Gerardo Gilligan, and Eduardo Piemonte, and Jerónimo Lazos, and María Celeste Simancas, and René Panico, and Saman Warnakulasuriya
January 1979, Leprosy in India,
Gerardo Gilligan, and Eduardo Piemonte, and Jerónimo Lazos, and María Celeste Simancas, and René Panico, and Saman Warnakulasuriya
January 2005, Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
Gerardo Gilligan, and Eduardo Piemonte, and Jerónimo Lazos, and María Celeste Simancas, and René Panico, and Saman Warnakulasuriya
January 2022, Journal of cutaneous medicine and surgery,
Gerardo Gilligan, and Eduardo Piemonte, and Jerónimo Lazos, and María Celeste Simancas, and René Panico, and Saman Warnakulasuriya
January 2011, Acta orthopaedica et traumatologica turcica,
Gerardo Gilligan, and Eduardo Piemonte, and Jerónimo Lazos, and María Celeste Simancas, and René Panico, and Saman Warnakulasuriya
March 2016, The Journal of dermatology,
Gerardo Gilligan, and Eduardo Piemonte, and Jerónimo Lazos, and María Celeste Simancas, and René Panico, and Saman Warnakulasuriya
December 1996, Leprosy review,
Gerardo Gilligan, and Eduardo Piemonte, and Jerónimo Lazos, and María Celeste Simancas, and René Panico, and Saman Warnakulasuriya
January 1964, International journal of Leprosy,
Gerardo Gilligan, and Eduardo Piemonte, and Jerónimo Lazos, and María Celeste Simancas, and René Panico, and Saman Warnakulasuriya
September 2019, The British journal of dermatology,
Gerardo Gilligan, and Eduardo Piemonte, and Jerónimo Lazos, and María Celeste Simancas, and René Panico, and Saman Warnakulasuriya
January 2001, International orthopaedics,
Gerardo Gilligan, and Eduardo Piemonte, and Jerónimo Lazos, and María Celeste Simancas, and René Panico, and Saman Warnakulasuriya
May 1979, Canadian journal of surgery. Journal canadien de chirurgie,
Copied contents to your clipboard!