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A rare case of a large Brunner's glands adenoma is reported. Usually, these neoplasms are small, exceeding 1 cm only in a few cases. Although the tumor was considerably large (6.5 cm), it did not cause obstruction of the upper digestive tract and bleeding was the first clinical symptom. Diagnosis was established after endoscopy with biopsies, which excluded malignancy. Local surgical excision of the neoplasm, which is the treatment of choice in such cases, was successfully performed.
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