Biomaterial Database

The use of thiphenamil hydrochloride (Trocinate) to control wound contraction after radial keratotomy. 1987

C Garrett, and E Presley, and T C Prager, and L C Moorhead

We studied the efficacy of a topical smooth muscle antagonist, thiphenamil hydrochloride (Trocinate), in inhibiting wound contraction in ocular tissue. Fifteen New Zealand white rabbits underwent standard eight-incision radial keratotomy (RK), and eyes were randomly assigned to treatment or control groups. As demonstrated by slit lamp corneal photographs and by ocular histology, transient inhibition of wound contraction lasted approximately one week in all treatment eyes. We conclude that thiphenamil has a temporary, but specific, effect in controlling wound contraction after ocular surgery. Smooth muscle antagonists may be useful for managing cicatricial conditions of the eye.

UI	MeSH Term	Description	Entries
D007646	Keratotomy, Radial	A procedure to surgically correct REFRACTIVE ERRORS by cutting radial slits into the CORNEA to change its refractive properties.	Radial Keratotomy,Keratotomies, Radial,Radial Keratotomies
D009130	Muscle, Smooth	Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)	Muscle, Involuntary,Smooth Muscle,Involuntary Muscle,Involuntary Muscles,Muscles, Involuntary,Muscles, Smooth,Smooth Muscles
D011817	Rabbits	A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes.	Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D003315	Cornea	The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)	Corneas
D004158	Diphenylacetic Acids	Monocarboxylic acid derivatives of acetic acids, where the methyl hydrogens have been replaced by two phenyl groups.	Acids, Diphenylacetic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013457	Sulfur Compounds	Inorganic or organic compounds that contain sulfur as an integral part of the molecule.	Sulfur Compound,Compound, Sulfur,Compounds, Sulfur
D014945	Wound Healing	Restoration of integrity to traumatized tissue.	Healing, Wound,Healings, Wound,Wound Healings