Skeletal Muscle Complications in Chronic Kidney Disease. 2022

Ashley D Troutman, and Eliott Arroyo, and Kenneth Lim, and Ranjani N Moorthi, and Keith G Avin
Department of Physical Therapy, School of Health and Human Sciences, Indiana University Purdue University, CF-326, 1140 W. Michigan St., Indianapolis, IN, 46202, USA.

To provide an overview of the recent literature investigating the pathophysiology of skeletal muscle changes, interventions for skeletal muscle, and effects of exercise in chronic kidney disease (CKD). There are multiple CKD-related changes that negatively impact muscle size and function. However, the variability in the assessment of muscle size, in particular, hinders the ability to truly understand the impact it may have in CKD. Exercise interventions to improve muscle size and function demonstrate inconsistent responses that warrant further investigation to optimize exercise prescription. Despite progress in the field, there are many gaps in the knowledge of the pathophysiology of sarcopenia of CKD. Identifying these gaps will help in the design of interventions that can be tested to target muscle loss and its consequences such as impaired mobility, falls, and poor quality of life in patients with CKD.

UI MeSH Term Description Entries
D011788 Quality of Life A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral, social environment as well as health and disease. HRQOL,Health-Related Quality Of Life,Life Quality,Health Related Quality Of Life
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015444 Exercise Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure. Aerobic Exercise,Exercise, Aerobic,Exercise, Isometric,Exercise, Physical,Isometric Exercise,Physical Activity,Acute Exercise,Exercise Training,Activities, Physical,Activity, Physical,Acute Exercises,Aerobic Exercises,Exercise Trainings,Exercise, Acute,Exercises,Exercises, Acute,Exercises, Aerobic,Exercises, Isometric,Exercises, Physical,Isometric Exercises,Physical Activities,Physical Exercise,Physical Exercises,Training, Exercise,Trainings, Exercise
D051436 Renal Insufficiency, Chronic Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002) Kidney Insufficiency, Chronic,Chronic Kidney Diseases,Chronic Kidney Insufficiency,Chronic Renal Diseases,Chronic Renal Insufficiency,Chronic Kidney Disease,Chronic Kidney Insufficiencies,Chronic Renal Disease,Chronic Renal Insufficiencies,Disease, Chronic Kidney,Disease, Chronic Renal,Diseases, Chronic Kidney,Diseases, Chronic Renal,Kidney Disease, Chronic,Kidney Diseases, Chronic,Kidney Insufficiencies, Chronic,Renal Disease, Chronic,Renal Diseases, Chronic,Renal Insufficiencies, Chronic
D055948 Sarcopenia Progressive decline in muscle mass due to aging which results in decreased functional capacity of muscles. Sarcopenias
D018482 Muscle, Skeletal A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles. Anterior Tibial Muscle,Gastrocnemius Muscle,Muscle, Voluntary,Plantaris Muscle,Skeletal Muscle,Soleus Muscle,Muscle, Anterior Tibial,Muscle, Gastrocnemius,Muscle, Plantaris,Muscle, Soleus,Muscles, Skeletal,Muscles, Voluntary,Skeletal Muscles,Tibial Muscle, Anterior,Voluntary Muscle,Voluntary Muscles

Related Publications

Ashley D Troutman, and Eliott Arroyo, and Kenneth Lim, and Ranjani N Moorthi, and Keith G Avin
October 2022, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,
Ashley D Troutman, and Eliott Arroyo, and Kenneth Lim, and Ranjani N Moorthi, and Keith G Avin
January 1971, Clinical orthopaedics and related research,
Ashley D Troutman, and Eliott Arroyo, and Kenneth Lim, and Ranjani N Moorthi, and Keith G Avin
January 2013, International journal of clinical and experimental medicine,
Ashley D Troutman, and Eliott Arroyo, and Kenneth Lim, and Ranjani N Moorthi, and Keith G Avin
March 2023, Physiological reports,
Ashley D Troutman, and Eliott Arroyo, and Kenneth Lim, and Ranjani N Moorthi, and Keith G Avin
August 2015, Kidney international,
Ashley D Troutman, and Eliott Arroyo, and Kenneth Lim, and Ranjani N Moorthi, and Keith G Avin
January 2016, PloS one,
Ashley D Troutman, and Eliott Arroyo, and Kenneth Lim, and Ranjani N Moorthi, and Keith G Avin
March 2020, JCI insight,
Ashley D Troutman, and Eliott Arroyo, and Kenneth Lim, and Ranjani N Moorthi, and Keith G Avin
February 2024, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
Ashley D Troutman, and Eliott Arroyo, and Kenneth Lim, and Ranjani N Moorthi, and Keith G Avin
September 2020, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
Ashley D Troutman, and Eliott Arroyo, and Kenneth Lim, and Ranjani N Moorthi, and Keith G Avin
June 2014, Kidney international,
Copied contents to your clipboard!