-transparent.png){kind=logo}
Humoral hypercalcemia of malignancy is a common complication of lung and certain other cancers. The hypercalcemia results from the actions of tumor factors on bone and kidney. We report here the isolation of full-length complementary DNA clones of a putative hypercalcemia factor, and the expression from the cloned DNA of the active protein in mammalian cells. The clones encode a prepro peptide of 36 amino acids and a mature protein of 141 amino acids that has significant homology with parathyroid hormone in the amino-terminal region. This previously unrecognized hormone may be important in normal as well as abnormal calcium metabolism.
Related Publications
L J Suva, and
G A Winslow, and
R E Wettenhall, and
R G Hammonds, and
J M Moseley, and
H Diefenbach-Jagger, and
C P Rodda, and
B E Kemp, and
H Rodriguez, and
E Y Chen
May 1991,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
L J Suva, and
G A Winslow, and
R E Wettenhall, and
R G Hammonds, and
J M Moseley, and
H Diefenbach-Jagger, and
C P Rodda, and
B E Kemp, and
H Rodriguez, and
E Y Chen
January 1998,
Hormone research,
L J Suva, and
G A Winslow, and
R E Wettenhall, and
R G Hammonds, and
J M Moseley, and
H Diefenbach-Jagger, and
C P Rodda, and
B E Kemp, and
H Rodriguez, and
E Y Chen
October 1997,
Cancer,
L J Suva, and
G A Winslow, and
R E Wettenhall, and
R G Hammonds, and
J M Moseley, and
H Diefenbach-Jagger, and
C P Rodda, and
B E Kemp, and
H Rodriguez, and
E Y Chen
November 1999,
International journal of dermatology,
L J Suva, and
G A Winslow, and
R E Wettenhall, and
R G Hammonds, and
J M Moseley, and
H Diefenbach-Jagger, and
C P Rodda, and
B E Kemp, and
H Rodriguez, and
E Y Chen
January 2000,
Clinica chimica acta; international journal of clinical chemistry,
L J Suva, and
G A Winslow, and
R E Wettenhall, and
R G Hammonds, and
J M Moseley, and
H Diefenbach-Jagger, and
C P Rodda, and
B E Kemp, and
H Rodriguez, and
E Y Chen
July 2002,
Journal of the American Veterinary Medical Association,
L J Suva, and
G A Winslow, and
R E Wettenhall, and
R G Hammonds, and
J M Moseley, and
H Diefenbach-Jagger, and
C P Rodda, and
B E Kemp, and
H Rodriguez, and
E Y Chen
December 1993,
Liver,
L J Suva, and
G A Winslow, and
R E Wettenhall, and
R G Hammonds, and
J M Moseley, and
H Diefenbach-Jagger, and
C P Rodda, and
B E Kemp, and
H Rodriguez, and
E Y Chen
August 1992,
Internal medicine (Tokyo, Japan),
L J Suva, and
G A Winslow, and
R E Wettenhall, and
R G Hammonds, and
J M Moseley, and
H Diefenbach-Jagger, and
C P Rodda, and
B E Kemp, and
H Rodriguez, and
E Y Chen
August 1994,
Leukemia & lymphoma,
L J Suva, and
G A Winslow, and
R E Wettenhall, and
R G Hammonds, and
J M Moseley, and
H Diefenbach-Jagger, and
C P Rodda, and
B E Kemp, and
H Rodriguez, and
E Y Chen
October 1995,
The American journal of gastroenterology,
