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Sex differences on the response to antidepressants and psychobiotics following early life stress in rats. 2022
Anelise S Carlessi, and
Maria Eduarda M Botelho, and
Luana M Manosso, and
Laura A Borba, and
Larissa R Maciel, and
Natalia M Andrade, and
Nicoly S Martinello, and
Alex Paulo Z Padilha, and
Camille M Generoso, and
Clara Vitória Bencke, and
Airam B de Moura, and
Bruna F Lodetti, and
Allan Collodel, and
Larissa Joaquim, and
Sandra Bonfante, and
Erica Biehl, and
Jaqueline S Generoso, and
Camila O Arent, and
Tatiana Barichello, and
Fabricia Petronilho, and
João Quevedo, and
Gislaine Z Réus
Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciuma, SC, Brazil.
Major depressive disorder (MDD) is the most prevalent mood disorder globally. Most antidepressants available for the treatment of MDD increase the concentration of monoamines in the synaptic cleft. However, such drugs have a high latency time to obtain benefits. Thus, new antidepressants with fast action and robust efficacy are very important. This study evaluated the effects of escitalopram, ketamine, and probiotic Bifidobacterium infantis in rats submitted to the maternal deprivation (MD). MD rats received saline, escitalopram, ketamine, or probiotic for 10, 30, or 50 days, depending on the postnatal day (PND):21, 41, and 61. Following behavior, this study examined the integrity of the blood-brain barrier (BBB) and oxidative stress markers. MD induced depressive-like behavior in females with PND21 and males with PND61. All treatments reversed depressive-like behavior in females and escitalopram and ketamine in males. MD induced an increase in the permeability of the BBB, an imbalance between oxidative stress and antioxidant defenses. Treatments regulated the oxidative damage and the integrity of the BBB induced by MD. The treatment with escitalopram, ketamine, or probiotics may prevent behavioral and neurochemical changes associated with MDD, depending on the developmental period and gender.
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Airam B de Moura, and
Bruna F Lodetti, and
Allan Collodel, and
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Sandra Bonfante, and
Erica Biehl, and
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Alex Paulo Z Padilha, and
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Airam B de Moura, and
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Erica Biehl, and
Jaqueline S Generoso, and
Camila O Arent, and
Tatiana Barichello, and
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João Quevedo, and
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Physiology & behavior,
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Maria Eduarda M Botelho, and
Luana M Manosso, and
Laura A Borba, and
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Natalia M Andrade, and
Nicoly S Martinello, and
Alex Paulo Z Padilha, and
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Clara Vitória Bencke, and
Airam B de Moura, and
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Luana M Manosso, and
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Nicoly S Martinello, and
Alex Paulo Z Padilha, and
Camille M Generoso, and
Clara Vitória Bencke, and
Airam B de Moura, and
Bruna F Lodetti, and
Allan Collodel, and
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Sandra Bonfante, and
Erica Biehl, and
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Luana M Manosso, and
Laura A Borba, and
Larissa R Maciel, and
Natalia M Andrade, and
Nicoly S Martinello, and
Alex Paulo Z Padilha, and
Camille M Generoso, and
Clara Vitória Bencke, and
Airam B de Moura, and
Bruna F Lodetti, and
Allan Collodel, and
Larissa Joaquim, and
Sandra Bonfante, and
Erica Biehl, and
Jaqueline S Generoso, and
Camila O Arent, and
Tatiana Barichello, and
Fabricia Petronilho, and
João Quevedo, and
Gislaine Z Réus
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Cell stress & chaperones,
