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This study examines the temporal pattern of hair cell loss in the chick basilar papilla following ten days of gentamicin administration in hatchling chicks. Chicks were subsequently killed at ages 11, 18, 25, and 32 days. The basilar papillae were embedded in plastic and serially sectioned for light microscopic analysis. Hair cell counts were obtained at 100-microM intervals throughout the length of the papilla. Significant hair cell loss was documented basally in the 11-day-old chicks, and spread apically over time to maximal loss in the 18-day-old animals. Relative to the control chicks, there was a 36% hair cell loss in these animals. Interestingly, there appears to be a progressive partial recovery of the normal hair cell counts in the 25- and 32-day-old animals.
R M Cruz, and
P R Lambert, and
E W Rubel
January 1999,
Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia,
R M Cruz, and
P R Lambert, and
E W Rubel
January 1994,
Zhonghua er bi yan hou ke za zhi,
R M Cruz, and
P R Lambert, and
E W Rubel
November 1991,
Hearing research,
R M Cruz, and
P R Lambert, and
E W Rubel
August 1992,
Journal of cell science,
R M Cruz, and
P R Lambert, and
E W Rubel
June 1998,
Hearing research,
R M Cruz, and
P R Lambert, and
E W Rubel
April 1991,
Hearing research,
R M Cruz, and
P R Lambert, and
E W Rubel
January 1987,
Hearing research,
R M Cruz, and
P R Lambert, and
E W Rubel
May 1997,
The Annals of otology, rhinology & laryngology. Supplement,
R M Cruz, and
P R Lambert, and
E W Rubel
September 1995,
Hearing research,
R M Cruz, and
P R Lambert, and
E W Rubel
March 2015,
Expert opinion on biological therapy,
