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The in vitro response to X-irradiation of cultured human fibroblasts was studied using a colony forming assay. A comprehensive reference range was established, giving a median D0 value of 98.5 cGy with an interquartile range of 86.5-110.5 cGy. Cells from 3 retinoblastoma family pedigrees were studied and the cell survival after exposure to X-rays was compared between affected (11 samples) and unaffected (26 samples) family members. No significant differences in response to ionising radiation were found between the controls, the affected and the unaffected members of the 3 families. The affected members had a median D0 of 97.5 cGy (interquartile range 87.5-107.5 cGy) and the unaffected members had a median D0 of 102 cGy (interquartile range 93-111 cGy). Thus radiosensitivity is not a useful marker for the detection of the retinoblastoma gene.
J V Pledger, and
A W Craft, and
K Bartlett, and
D R Long
August 1978,
Proceedings of the National Academy of Sciences of the United States of America,
J V Pledger, and
A W Craft, and
K Bartlett, and
D R Long
July 1983,
Investigative ophthalmology & visual science,
J V Pledger, and
A W Craft, and
K Bartlett, and
D R Long
April 1985,
International journal of radiation biology and related studies in physics, chemistry, and medicine,
J V Pledger, and
A W Craft, and
K Bartlett, and
D R Long
January 1992,
Anticancer research,
J V Pledger, and
A W Craft, and
K Bartlett, and
D R Long
June 2002,
International journal of cancer,
J V Pledger, and
A W Craft, and
K Bartlett, and
D R Long
May 1983,
Mutation research,
J V Pledger, and
A W Craft, and
K Bartlett, and
D R Long
August 1982,
Journal of ophthalmic nursing & technology,
J V Pledger, and
A W Craft, and
K Bartlett, and
D R Long
September 1981,
Cancer research,
J V Pledger, and
A W Craft, and
K Bartlett, and
D R Long
December 1986,
Cancer research,
J V Pledger, and
A W Craft, and
K Bartlett, and
D R Long
April 1977,
Nature,
