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Rats were subjected to 60% partial hepatectomy. In the immediate postoperative period, there was a small decline in plasma fibronectin concentrations, which was normalized already 12 h post-operatively. Metabolic labelling of fibronectin with 35S-methionine showed that the rate of incorporation of label was unchanged after partial hepatectomy. However, when the abdominal viscera were excluded from the circulation, no incorporation of label was found. These results show that the rate of fibronectin biosynthesis has the rapid regulation characteristics of an acute phase reactant. Peripheral tissues do not contribute significantly to the plasma fibronectin concentration. Intra- or retro-peritoneal viscera, most likely the liver, are responsible for the synthesis of rat plasma fibronectin.
T K Nilsson, and
L Domellöf, and
L Berghem
September 2008,
Carbohydrate research,
T K Nilsson, and
L Domellöf, and
L Berghem
November 1964,
The Journal of surgical research,
T K Nilsson, and
L Domellöf, and
L Berghem
August 1996,
Biochemistry and molecular biology international,
T K Nilsson, and
L Domellöf, and
L Berghem
April 2023,
Biotechnic & histochemistry : official publication of the Biological Stain Commission,
T K Nilsson, and
L Domellöf, and
L Berghem
February 1992,
Clinical science (London, England : 1979),
T K Nilsson, and
L Domellöf, and
L Berghem
April 2004,
The Journal of surgical research,
T K Nilsson, and
L Domellöf, and
L Berghem
May 1990,
Acta anaesthesiologica Scandinavica,
T K Nilsson, and
L Domellöf, and
L Berghem
January 1958,
Rivista di gastro-enterologia,
T K Nilsson, and
L Domellöf, and
L Berghem
March 2003,
Journal of physiology and biochemistry,
T K Nilsson, and
L Domellöf, and
L Berghem
November 1993,
Journal of hepatology,
