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Strain SV3 of Salmonella typhimurium is sensitive to arabinose, that is, unable to grow in a medium containing arabinose plus glycerol as carbon source. Arabinose resistance is the consequence of the mutational inactivation of one of at least three different genes. The selection of arabinose-resistant mutants provides a simple and sensitive assay for the detection of weak mutagens and for refined quantitative studies of strong ones. The assay is not influenced by experimental artifacts derived from physiological or lethal effects or from differences in plating density. Such artifacts are common with other bacterial mutagen assays, including those using strains analogous to SV3. As practical examples, the assay was used with N-methyl-N'-nitro-N-nitrosoguanidine and the fungicide captafol.
R Ruiz-Vázquez, and
C Pueyo, and
E Cerdá-Olmedo
December 1978,
Mutation research,
R Ruiz-Vázquez, and
C Pueyo, and
E Cerdá-Olmedo
June 1979,
Mutation research,
R Ruiz-Vázquez, and
C Pueyo, and
E Cerdá-Olmedo
August 1979,
Mutation research,
R Ruiz-Vázquez, and
C Pueyo, and
E Cerdá-Olmedo
February 1988,
Mutation research,
R Ruiz-Vázquez, and
C Pueyo, and
E Cerdá-Olmedo
January 1993,
IARC scientific publications,
R Ruiz-Vázquez, and
C Pueyo, and
E Cerdá-Olmedo
December 1979,
The Journal of bone and joint surgery. American volume,
R Ruiz-Vázquez, and
C Pueyo, and
E Cerdá-Olmedo
April 1947,
Acta medica Orientalia,
R Ruiz-Vázquez, and
C Pueyo, and
E Cerdá-Olmedo
January 1990,
La Medicina del lavoro,
R Ruiz-Vázquez, and
C Pueyo, and
E Cerdá-Olmedo
October 1982,
Mutation research,
R Ruiz-Vázquez, and
C Pueyo, and
E Cerdá-Olmedo
May 1975,
Indian journal of experimental biology,
