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A series of sixteen 2-, 4- and 5-nitroimidazoles, four nitrobenzenes, five nitrofurans, and a nitropyrrole, most of which have been studied previously as hypoxic cell specific radiosensitizers, have been screened for their mutagenicity using the Salmonella typhimurium strains TA 100 and TA 98 developed by Ames and co-workers. Most of these compounds were mutagenic and had a one to two order of magnitude greater mutagenicity towards TA 100 (base-pair substitution sensitive) than TA 98 (frame-shift sensitive). The spectrum of mutagenic efficiencies for the drugs which was observed could be correlated to some extent with the electron affinity of these compounds. Exceptions to this correlation may indicate drugs of interest for further studies both as mutagens and hypoxic cell radiosensitizers.
J B Chin, and
D M Sheinin, and
A M Rauth
October 1984,
Cancer research,
J B Chin, and
D M Sheinin, and
A M Rauth
January 1985,
Chemico-biological interactions,
J B Chin, and
D M Sheinin, and
A M Rauth
January 1987,
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences,
J B Chin, and
D M Sheinin, and
A M Rauth
September 1987,
Mutation research,
J B Chin, and
D M Sheinin, and
A M Rauth
January 1991,
Environmental and molecular mutagenesis,
J B Chin, and
D M Sheinin, and
A M Rauth
September 1997,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
J B Chin, and
D M Sheinin, and
A M Rauth
April 1982,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
J B Chin, and
D M Sheinin, and
A M Rauth
January 2001,
Environmental and molecular mutagenesis,
J B Chin, and
D M Sheinin, and
A M Rauth
November 2023,
Drug and chemical toxicology,
J B Chin, and
D M Sheinin, and
A M Rauth
September 1985,
Mutation research,
