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The present study was aimed to demonstrate that cytochrome P-450 was induced by drug administration in particular tissues in the eye. Phenobarbital was used as an inducer. We showed immunohistochemically that cytochrome P-450 was induced in the cornea, conjunctiva and ciliary epithelium of rabbits after four days of intraperitoneal administration of phenobarbital at a dose of 80 mg per kg per day. We did not detect significant immunofluorescence in other ocular tissues. Prolonged administration caused degeneration of the ciliary epithelium, but not pathological change was seen in other ocular tissues. In this case, immunofluorescence was not detected in the ciliary epithelium but in the cornea, conjunctiva and lens.
K Matsumoto, and
K Kishida, and
R Manabe, and
T Sugiyama
January 1978,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
K Matsumoto, and
K Kishida, and
R Manabe, and
T Sugiyama
October 1981,
The Journal of biological chemistry,
K Matsumoto, and
K Kishida, and
R Manabe, and
T Sugiyama
January 1993,
European journal of histochemistry : EJH,
K Matsumoto, and
K Kishida, and
R Manabe, and
T Sugiyama
February 1992,
The Biochemical journal,
K Matsumoto, and
K Kishida, and
R Manabe, and
T Sugiyama
January 1982,
Enzyme,
K Matsumoto, and
K Kishida, and
R Manabe, and
T Sugiyama
July 1987,
Biokhimiia (Moscow, Russia),
K Matsumoto, and
K Kishida, and
R Manabe, and
T Sugiyama
January 1987,
Pharmacology & therapeutics,
K Matsumoto, and
K Kishida, and
R Manabe, and
T Sugiyama
July 1986,
Biokhimiia (Moscow, Russia),
K Matsumoto, and
K Kishida, and
R Manabe, and
T Sugiyama
July 1985,
Biochemical pharmacology,
K Matsumoto, and
K Kishida, and
R Manabe, and
T Sugiyama
March 1968,
Cancer research,
