Biomaterial Database

Intrinsic jejunal propulsion in the guinea pig during parasitism with Trichinella spiralis. 1987

H Alizadeh, and G A Castro, and W A Weems

The onset and duration of alterations in intrinsic fluid propelling behavior of guinea pig jejunum caused by infection with Trichinella spiralis was determined using an in vitro monitoring system. Isolated intestinal segments from uninfected hosts produced propulsive complexes of approximately 30-s duration at 125-s intervals. The maximum intraluminal pressure produced at the oral and aboral ends of the segments was approximately 25 cmH2O and the maximum rate of fluid ejection in both the oral and aboral directions was approximately 0.28 ml/s. Segments removed from guinea pigs 10 and 15 days after being inoculated with infective parasite larvae ejected significantly more fluid in the aboral as compared with the oral direction. The maximum aboral pressure developed 10 days postinoculation was 45.7 cmH2O and the maximum aboral fluid ejection rate was 0.60 ml/s. Analogous oral values were 29.0 cmH2O and 0.40 ml/s. This net aboral propulsion was not observed on days 7, 20, 30, or 60 postinoculation. We conclude that precise and highly predictable alterations in intrinsic propulsive behavior of the small intestine are induced by primary infection. These changes are expressed by day 10 postinoculation and are reversed upon spontaneous termination of the intestinal phase of parasitism.

UI	MeSH Term	Description	Entries
D007583	Jejunum	The middle portion of the SMALL INTESTINE, between DUODENUM and ILEUM. It represents about 2/5 of the remaining portion of the small intestine below duodenum.	Jejunums
D008297	Male		Males
D009130	Muscle, Smooth	Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)	Muscle, Involuntary,Smooth Muscle,Involuntary Muscle,Involuntary Muscles,Muscles, Involuntary,Muscles, Smooth,Smooth Muscles
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D006874	Hydrostatic Pressure	The pressure due to the weight of fluid.	Hydrostatic Pressures,Pressure, Hydrostatic,Pressures, Hydrostatic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001696	Biomechanical Phenomena	The properties, processes, and behavior of biological systems under the action of mechanical forces.	Biomechanics,Kinematics,Biomechanic Phenomena,Mechanobiological Phenomena,Biomechanic,Biomechanic Phenomenas,Phenomena, Biomechanic,Phenomena, Biomechanical,Phenomena, Mechanobiological,Phenomenas, Biomechanic
D014235	Trichinellosis	An infection with TRICHINELLA. It is caused by eating raw or undercooked meat that is infected with larvae of nematode worms TRICHINELLA genus. All members of the TRICHINELLA genus can infect human in addition to TRICHINELLA SPIRALIS, the traditional etiological agent. It is distributed throughout much of the world and is re-emerging in some parts as a public health hazard and a food safety problem.	Human Trichinellosis,Trichinelliasis,Trichinosis,Human Trichinelloses,Trichinelliases,Trichinelloses,Trichinelloses, Human,Trichinellosis, Human,Trichinoses
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In