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Morpholine oleic acid salt (MOAS) was administered to groups of 50 male and 50 female B6C3F1 mice in the drinking-water at levels of 0, 0.25 and 1.0%. Both sexes given 1.0% MOAS and females given 0.25% showed growth retardation. Significant increases in blood-urea nitrogen concentrations were only observed in the 1.0% male group. The incidence of squamous-cell hyperplasia of the forestomach epithelium was significantly higher in the males given 1.0% than in the controls. The male mice given 0.25% MOAS had a significantly reduced incidence of hepatocellular carcinoma in comparison with the control group and this trend was indicated also in the 1.0% group. This experiment did not demonstrate any carcinogenic effect of MOAS in mice at levels up to 1.0% in the drinking-water.
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Y Kurata, and
T Ogiso, and
S Tamano, and
S Fukushima, and
N Ito
January 1992,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
M A Shibata, and
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S Tamano, and
S Fukushima, and
N Ito
July 1989,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
M A Shibata, and
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July 1993,
Fundamental and applied toxicology : official journal of the Society of Toxicology,
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Fundamental and applied toxicology : official journal of the Society of Toxicology,
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Environmental health perspectives,
M A Shibata, and
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Fundamental and applied toxicology : official journal of the Society of Toxicology,
M A Shibata, and
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Toxicologic pathology,
M A Shibata, and
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Drug and chemical toxicology,
M A Shibata, and
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S Fukushima, and
N Ito
May 1992,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
M A Shibata, and
Y Kurata, and
T Ogiso, and
S Tamano, and
S Fukushima, and
N Ito
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
