| D006801 |
Humans |
Members of the species Homo sapiens. |
Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man |
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| D017209 |
Apoptosis |
A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. |
Apoptosis, Extrinsic Pathway,Apoptosis, Intrinsic Pathway,Caspase-Dependent Apoptosis,Classic Apoptosis,Classical Apoptosis,Programmed Cell Death,Programmed Cell Death, Type I,Apoptoses, Extrinsic Pathway,Apoptoses, Intrinsic Pathway,Apoptosis, Caspase-Dependent,Apoptosis, Classic,Apoptosis, Classical,Caspase Dependent Apoptosis,Cell Death, Programmed,Classic Apoptoses,Extrinsic Pathway Apoptoses,Extrinsic Pathway Apoptosis,Intrinsic Pathway Apoptoses,Intrinsic Pathway Apoptosis |
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| D045744 |
Cell Line, Tumor |
A cell line derived from cultured tumor cells. |
Tumor Cell Line,Cell Lines, Tumor,Line, Tumor Cell,Lines, Tumor Cell,Tumor Cell Lines |
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| D053220 |
Receptors, TNF-Related Apoptosis-Inducing Ligand |
Tumor necrosis factor receptor family members that are widely expressed and play a role in regulation of peripheral immune responses and APOPTOSIS. The receptors are specific for TNF-RELATED APOPTOSIS-INDUCING LIGAND and signal via conserved DEATH DOMAINS that associate with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. |
Decoy Receptor 2, Tumor Necrosis Factor,Receptors, TRAIL,Receptors, Tumor Necrosis Factor, Member 10,Receptors, Tumor Necrosis Factor, Member 10b,TNF-Related Apoptosis-Inducing Ligand Receptors,Tumor Necrosis Factor Receptor Superfamily, Member 10,APO2 Receptor,CD261 Antigen,CD262 Antigen,CD264 Antigen,DCR2 Receptor,DR4 Receptor,DR5 Receptor,Death Receptor-4,Death Receptor-5,Receptor, TRAIL-1,Receptor, TRAIL-2,Receptor, TRAIL-4,Receptors, Tumor Necrosis Factor, Member 10a,Receptors, Tumor Necrosis Factor, Member 10d,TNF-Related Apoptosis-Inducing Ligand Receptor 2,TRAIL Receptor 1,TRAIL Receptor 2,TRAIL Receptor 4,TRAIL Receptors,Tumor Necrosis Factor Receptor Superfamily, Member 10a,Tumor Necrosis Factor Receptor Superfamily, Member 10b,Antigen, CD261,Antigen, CD262,Antigen, CD264,Death Receptor 4,Death Receptor 5,Receptor 4, TRAIL,Receptor, APO2,Receptor, DCR2,Receptor, DR4,Receptor, DR5,Receptor, TRAIL 1,Receptor, TRAIL 2,Receptor, TRAIL 4,Receptor-4, Death,Receptors, TNF Related Apoptosis Inducing Ligand,TNF Related Apoptosis Inducing Ligand Receptor 2,TNF Related Apoptosis Inducing Ligand Receptors,TRAIL-1 Receptor,TRAIL-2 Receptor,TRAIL-4 Receptor |
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| D053221 |
TNF-Related Apoptosis-Inducing Ligand |
A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form. |
Tumor Necrosis Factor Ligand Superfamily Member 10,Apo-2 Ligand,Apo-2L Protein,CD253 Antigen,TNF Superfamily, Member 10,TRAIL Protein,Antigen, CD253,Apo 2 Ligand,Apo 2L Protein,Apoptosis-Inducing Ligand, TNF-Related,TNF Related Apoptosis Inducing Ligand |
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| D060890 |
B7-H1 Antigen |
An inhibitory B7 antigen that contains V-type and C2 type immunoglobulin domains. It has specificity for the T-CELL receptor PROGRAMMED CELL DEATH 1 PROTEIN and provides negative signals that control and inhibit T-cell responses. It is found at higher than normal levels on tumor cells, suggesting its potential role in TUMOR IMMUNE EVASION. |
Antigens, CD274,PD-L1 Protein,Programmed Cell Death 1 Ligand 1 Protein,Programmed Death Ligand 1,B7-H1 Immune Costimulatory Protein,B7H1 Immune Costimulatory Protein,CD274 Antigen,PD-L1 Costimulatory Protein,Programmed Cell Death 1 Ligand 1,Antigen, B7-H1,Antigen, CD274,B7 H1 Antigen,B7 H1 Immune Costimulatory Protein,CD274 Antigens,Costimulatory Protein, PD-L1,PD L1 Costimulatory Protein,PD L1 Protein |
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| D064726 |
Triple Negative Breast Neoplasms |
Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN. |
ER-Negative PR-Negative HER2-Negative Breast Cancer,ER-Negative PR-Negative HER2-Negative Breast Neoplasms,Triple Negative Breast Cancer,Triple-Negative Breast Cancer,Triple-Negative Breast Neoplasm,Breast Cancer, Triple-Negative,Breast Cancers, Triple-Negative,Breast Neoplasm, Triple-Negative,Breast Neoplasms, Triple-Negative,ER Negative PR Negative HER2 Negative Breast Cancer,ER Negative PR Negative HER2 Negative Breast Neoplasms,Triple Negative Breast Neoplasm,Triple-Negative Breast Cancers,Triple-Negative Breast Neoplasms |
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