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Hepatitis B Virus (HBV) Replication During Tenofovir Therapy Is Frequent in Human Immunodeficiency Virus/HBV Coinfection. 2023
Eveline Hofmann, and
Bernard Surial, and
Noémie Boillat-Blanco, and
Huldrych F Günthard, and
Marcel Stöckle, and
Enos Bernasconi, and
Patrick Schmid, and
Alexandra Calmy, and
Franziska Suter-Riniker, and
Andri Rauch, and
Gilles Wandeler, and
Charles Béguelin, and
Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
In the Swiss HIV Cohort Study, 61 of 222 (27%) HIV-suppressed persons with chronic hepatitis B virus (HBV) infection had HBV replication after 2 years on tenofovir, of whom 77% were suppressed thereafter. Self-reported adherence to therapy and HBV viral load at tenofovir initiation were predictors of persistent replication.
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