A potential serological biomarker for inner ear pathologies: OTOLIN-1. 2022

Emilio Avallone, and Heike Schmitt, and Giorgio Lilli, and Athanasia Warnecke, and Anke Lesinski-Schiedat, and Thomas Lenarz, and Kerstin Willenborg
Department of Otorhinolaryngology, Head and Neck Surgery, Hannover Medical School, Hannover, Germany.

The goal of the study was to determine whether the level of OTOLIN-1, a protein whose expression is highly restricted to the inner ear,is increased in the body fluids of patients with inner ear disorders in comparison to healthy subjects. In the preliminary part of the study, OTOLIN-1 levels were measured in the serum, urine, and saliva of patients with an acute onset of Ménière´s disease and in healthy individuals. Subsequently, only serum OTOLIN-1 levels were taken into account and were compared between patients with acute onset of Ménière´s disease, sudden hearing loss, vestibular neuritis and healthy subjects. The most reliable diagnostic parameter was OTOLIN-1 levels in serum. Serum samples of patients with Ménière's disease and sudden hearing loss showed significantly higher OTOLIN-1 levels than those from healthy individuals. In addition, there was no significant difference between the serum concentration of OTOLIN-1 in patients with vestibular neuritis and the control group. Serum levels of OTOLIN-1 can potentially be used as a biomarker for acute onset of inner ear disorders due to its significant increase in patients with acute Meniere´s disease and sudden hearing loss in comparison to healthy individuals.

UI MeSH Term Description Entries
D007758 Ear, Inner The essential part of the hearing organ consists of two labyrinthine compartments: the bony labyrinthine and the membranous labyrinth. The bony labyrinth is a complex of three interconnecting cavities or spaces (COCHLEA; VESTIBULAR LABYRINTH; and SEMICIRCULAR CANALS) in the TEMPORAL BONE. Within the bony labyrinth lies the membranous labyrinth which is a complex of sacs and tubules (COCHLEAR DUCT; SACCULE AND UTRICLE; and SEMICIRCULAR DUCTS) forming a continuous space enclosed by EPITHELIUM and connective tissue. These spaces are filled with LABYRINTHINE FLUIDS of various compositions. Labyrinth,Bony Labyrinth,Ear, Internal,Inner Ear,Membranous Labyrinth,Bony Labyrinths,Ears, Inner,Ears, Internal,Inner Ears,Internal Ear,Internal Ears,Labyrinth, Bony,Labyrinth, Membranous,Labyrinths,Labyrinths, Bony,Labyrinths, Membranous,Membranous Labyrinths
D008575 Meniere Disease A disease of the inner ear (LABYRINTH) that is characterized by fluctuating SENSORINEURAL HEARING LOSS; TINNITUS; episodic VERTIGO; and aural fullness. It is the most common form of endolymphatic hydrops. Meniere's Disease,Meniere's Syndrome,Vertigo, Aural,Auditory Vertigo,Aural Vertigo,Ménière Disease,Ménière's Disease,Ménière's Vertigo,Otogenic Vertigo,Auditory Vertigos,Disease, Meniere,Disease, Meniere's,Disease, Ménière,Disease, Ménière's,Diseases, Ménière,Diseases, Ménière's,Meniere Syndrome,Menieres Disease,Menieres Syndrome,Ménière Diseases,Ménière Vertigo,Ménière's Diseases,Ménière's Vertigos,Ménières Disease,Ménières Vertigo,Otogenic Vertigos,Syndrome, Meniere's,Vertigo, Auditory,Vertigo, Ménière's,Vertigo, Otogenic,Vertigos, Auditory,Vertigos, Ménière's,Vertigos, Otogenic
D003639 Hearing Loss, Sudden Sensorineural hearing loss which develops suddenly over a period of hours or a few days. It varies in severity from mild to total deafness. Sudden deafness can be due to head trauma, vascular diseases, infections, or can appear without obvious cause or warning. Deafness, Sudden,Sudden Deafness,Sudden Hearing Loss
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015415 Biomarkers Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, ENVIRONMENTAL EXPOSURE and its effects, disease diagnosis; METABOLIC PROCESSES; SUBSTANCE ABUSE; PREGNANCY; cell line development; EPIDEMIOLOGIC STUDIES; etc. Biochemical Markers,Biological Markers,Biomarker,Clinical Markers,Immunologic Markers,Laboratory Markers,Markers, Biochemical,Markers, Biological,Markers, Clinical,Markers, Immunologic,Markers, Laboratory,Markers, Serum,Markers, Surrogate,Markers, Viral,Serum Markers,Surrogate Markers,Viral Markers,Biochemical Marker,Biologic Marker,Biologic Markers,Clinical Marker,Immune Marker,Immune Markers,Immunologic Marker,Laboratory Marker,Marker, Biochemical,Marker, Biological,Marker, Clinical,Marker, Immunologic,Marker, Laboratory,Marker, Serum,Marker, Surrogate,Serum Marker,Surrogate End Point,Surrogate End Points,Surrogate Endpoint,Surrogate Endpoints,Surrogate Marker,Viral Marker,Biological Marker,End Point, Surrogate,End Points, Surrogate,Endpoint, Surrogate,Endpoints, Surrogate,Marker, Biologic,Marker, Immune,Marker, Viral,Markers, Biologic,Markers, Immune
D016326 Extracellular Matrix Proteins Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ). Extracellular Matrix Protein,Matrix Protein, Extracellular,Matrix Proteins, Extracellular,Protein, Extracellular Matrix,Proteins, Extracellular Matrix
D020338 Vestibular Neuronitis Idiopathic inflammation of the VESTIBULAR NERVE, characterized clinically by the acute or subacute onset of VERTIGO; NAUSEA; and imbalance. The COCHLEAR NERVE is typically spared and HEARING LOSS and TINNITUS do not usually occur. Symptoms usually resolve over a period of days to weeks. (Adams et al., Principles of Neurology, 6th ed, p304) Epidemic Neurolabyrinthitis,Neuritis, Vestibular,Neuronitis, Vestibular,Acute Peripheral Vestibulopathy,Acute Vestibular Neuritis,Episodic Recurrent Vertigo,Recurrent Vestibular Neuritis,Recurrent Vestibulopathy,Subacute Vestibular Neuritis,Vestibular Nerve Inflammation,Vestibular Nerve Neuritis,Vestibular Neuritis,Vestibular Neuropathy,Acute Peripheral Vestibulopathies,Acute Vestibular Neuritides,Epidemic Neurolabyrinthitides,Episodic Recurrent Vertigos,Inflammation, Vestibular Nerve,Inflammations, Vestibular Nerve,Nerve Inflammation, Vestibular,Nerve Inflammations, Vestibular,Nerve Neuritides, Vestibular,Nerve Neuritis, Vestibular,Neuritides, Acute Vestibular,Neuritides, Recurrent Vestibular,Neuritides, Subacute Vestibular,Neuritides, Vestibular,Neuritides, Vestibular Nerve,Neuritis, Acute Vestibular,Neuritis, Recurrent Vestibular,Neuritis, Subacute Vestibular,Neuritis, Vestibular Nerve,Neurolabyrinthitides, Epidemic,Neurolabyrinthitis, Epidemic,Neuronitides, Vestibular,Neuropathies, Vestibular,Neuropathy, Vestibular,Peripheral Vestibulopathies, Acute,Peripheral Vestibulopathy, Acute,Recurrent Vertigo, Episodic,Recurrent Vertigos, Episodic,Recurrent Vestibular Neuritides,Recurrent Vestibulopathies,Subacute Vestibular Neuritides,Vertigo, Episodic Recurrent,Vertigos, Episodic Recurrent,Vestibular Nerve Inflammations,Vestibular Nerve Neuritides,Vestibular Neuritides,Vestibular Neuritides, Acute,Vestibular Neuritides, Recurrent,Vestibular Neuritides, Subacute,Vestibular Neuritis, Acute,Vestibular Neuritis, Recurrent,Vestibular Neuritis, Subacute,Vestibular Neuronitides,Vestibular Neuropathies,Vestibulopathies, Acute Peripheral,Vestibulopathies, Recurrent,Vestibulopathy, Acute Peripheral,Vestibulopathy, Recurrent

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