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Frequency detection of porcine circovirus-like viruses in pigs with porcine respiratory disease. 2022

Xifeng Hu, and Zheng Chen, and Deping Song, and Yu Li, and Zhen Ding, and Xiangdong Wu, and Hongnan You, and Huansheng Wu
Department of Preventive Veterinary Medicine, College of Animal Science and Technology, Jiangxi Agricultural University, Zhimin Street, Qingshan Lake, Nanchang 330045, PR China; Jiangxi Provincial Key laboratory for Animal Science and Technology, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, PR China.

The emergence of the circular replication-associated protein (Rep) encoding single-stranded (CRESS) DNA viruses in different hosts has been associated with serious diseases, such as porcine diarrhea. The prevalence and pathogenicity of porcine circovirus-like virus (Po-Circo-like virus (PCLV)), a member of CRESS DNA virus, has not been fully illustrated. In order to understand the frequency of PCLV in pigs with respiratory disease, 519 healthy tissues (268 lungs, 201 lymph nodes and 50 hearts) and 380 tissues (212 lungs, 124 lymph nodes and 44 hearts) diagnosed with respiratory disease were collected for analyzing the prevalence of the PCLV infection using the Tag-Man qPCR assay. In addition, the complete genome of 43 PCLV strains were then sequenced, which were subsequently to analyze their characteristics. We found that 31.7 % (285/899) samples were tested positive for PCL virus. It is interesting to note that just 9.6 % (50/519) of the healthy samples were tested positive for PCLV, 61.8 % (235/380) of the diseased samples were PCLV positive. Analysis of the full genome of 43 PCLV strains showed that the genome of 42 PCLV strains included two distinct stem-loop structures, but the genome of PCLV FJ5-2020 strain contained no stem-loop structures. A phylogenetic tree analysis based on the Rep protein, PCLV could be classified into four genotypes: PCLVa, PCLVb, PCLVc, and PCLVd. In conclusion, this is the first report that the high frequency of PCLV in association in respiratory diseased pigs. PCLV strains were divided into four new genotypes of PCLV.

UI MeSH Term Description Entries
D010802 Phylogeny The relationships of groups of organisms as reflected by their genetic makeup. Community Phylogenetics,Molecular Phylogenetics,Phylogenetic Analyses,Phylogenetic Analysis,Phylogenetic Clustering,Phylogenetic Comparative Analysis,Phylogenetic Comparative Methods,Phylogenetic Distance,Phylogenetic Generalized Least Squares,Phylogenetic Groups,Phylogenetic Incongruence,Phylogenetic Inference,Phylogenetic Networks,Phylogenetic Reconstruction,Phylogenetic Relatedness,Phylogenetic Relationships,Phylogenetic Signal,Phylogenetic Structure,Phylogenetic Tree,Phylogenetic Trees,Phylogenomics,Analyse, Phylogenetic,Analysis, Phylogenetic,Analysis, Phylogenetic Comparative,Clustering, Phylogenetic,Community Phylogenetic,Comparative Analysis, Phylogenetic,Comparative Method, Phylogenetic,Distance, Phylogenetic,Group, Phylogenetic,Incongruence, Phylogenetic,Inference, Phylogenetic,Method, Phylogenetic Comparative,Molecular Phylogenetic,Network, Phylogenetic,Phylogenetic Analyse,Phylogenetic Clusterings,Phylogenetic Comparative Analyses,Phylogenetic Comparative Method,Phylogenetic Distances,Phylogenetic Group,Phylogenetic Incongruences,Phylogenetic Inferences,Phylogenetic Network,Phylogenetic Reconstructions,Phylogenetic Relatednesses,Phylogenetic Relationship,Phylogenetic Signals,Phylogenetic Structures,Phylogenetic, Community,Phylogenetic, Molecular,Phylogenies,Phylogenomic,Reconstruction, Phylogenetic,Relatedness, Phylogenetic,Relationship, Phylogenetic,Signal, Phylogenetic,Structure, Phylogenetic,Tree, Phylogenetic
D004267 DNA Viruses Viruses whose nucleic acid is DNA. DNA Virus,Virus, DNA,Viruses, DNA
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013552 Swine Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA). Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D013553 Swine Diseases Diseases of domestic swine and of the wild boar of the genus Sus. Disease, Swine,Diseases, Swine,Swine Disease
D017925 Circovirus A genus of the family CIRCOVIRIDAE that infects SWINE; PSITTACINES; and non-psittacine BIRDS. Species include Beak and feather disease virus causing a fatal disease in psittacine birds, and Porcine circovirus causing postweaning multisystemic wasting syndrome in pigs (PORCINE POSTWEANING MULTISYSTEMIC WASTING SYNDROME). Beak and feather disease virus,Circovirus, Porcine,Porcine Circovirus,Circoviruses, Porcine,Porcine Circoviruses
D018173 Circoviridae Infections Virus diseases caused by the CIRCOVIRIDAE. Circovirus Infections,Infections, Circoviridae,Infections, Circovirus,Circoviridae Infection,Circovirus Infection,Infection, Circoviridae,Infection, Circovirus

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