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The present study describes the response to small oral doses (1--10 microgram/day) of 24,25-DHCC in man. Contrary to expectation, 24,25-DHCC was as potent as 1,25-DHCC in increasing intestinal absorption of calcium both in normal persons and in patients with a variety of disorders of calcium metabolism. Despite this increase in intestinal absorption, plasma and urine calcium did not increase after 24,25-DHCC as they did after 1,25-DHCC. Metabolic balance studies showed calcium balances to increase by 1.6 to 11.5 mmoles/day in 5 of the 6 patients studied. 24,25-DHCC increased intestinal absorption of calcium equally well in anephric patients, suggesting that conversion of 24,25-DHCC to 1,24,25-trihydroxycholecalciferol by the kidney cannot be the sole mechanism by which 24,25-DHCC expresses biological activity, even though in vitamin D deficient rats nephrectomy does abolish the ability of large doses of 24,25-DHCC to increase calcium absorption. It is concluded that 24,25-DHCC may be a calcium-regulating hormone in man. In view of the effects demonstrated here and its relatively high concentration in plasma and slow turnover rate, 24,25-DHCC has the properties that might be ideal for a long-acting stimulator of bone mineralisation. Further work is needed to explain why 24,25-DHCC has effects in man which are not readily seen in other species.
R G Russell, and
J A Kanis, and
R Smith, and
N D Adams, and
M Bartlett, and
T Cundy, and
M Cochran, and
G Heynen, and
G T Warner
January 1982,
Nephrologie,
R G Russell, and
J A Kanis, and
R Smith, and
N D Adams, and
M Bartlett, and
T Cundy, and
M Cochran, and
G Heynen, and
G T Warner
July 1984,
Clinical endocrinology,
R G Russell, and
J A Kanis, and
R Smith, and
N D Adams, and
M Bartlett, and
T Cundy, and
M Cochran, and
G Heynen, and
G T Warner
November 1991,
The Journal of nutrition,
R G Russell, and
J A Kanis, and
R Smith, and
N D Adams, and
M Bartlett, and
T Cundy, and
M Cochran, and
G Heynen, and
G T Warner
June 1976,
The Journal of nutrition,
R G Russell, and
J A Kanis, and
R Smith, and
N D Adams, and
M Bartlett, and
T Cundy, and
M Cochran, and
G Heynen, and
G T Warner
May 1977,
Calcified tissue research,
R G Russell, and
J A Kanis, and
R Smith, and
N D Adams, and
M Bartlett, and
T Cundy, and
M Cochran, and
G Heynen, and
G T Warner
June 1976,
Biochemical and biophysical research communications,
R G Russell, and
J A Kanis, and
R Smith, and
N D Adams, and
M Bartlett, and
T Cundy, and
M Cochran, and
G Heynen, and
G T Warner
January 1982,
Voprosy meditsinskoi khimii,
R G Russell, and
J A Kanis, and
R Smith, and
N D Adams, and
M Bartlett, and
T Cundy, and
M Cochran, and
G Heynen, and
G T Warner
October 1980,
Proceedings of the National Academy of Sciences of the United States of America,
R G Russell, and
J A Kanis, and
R Smith, and
N D Adams, and
M Bartlett, and
T Cundy, and
M Cochran, and
G Heynen, and
G T Warner
December 1976,
Calcified tissue research,
R G Russell, and
J A Kanis, and
R Smith, and
N D Adams, and
M Bartlett, and
T Cundy, and
M Cochran, and
G Heynen, and
G T Warner
January 1985,
Voprosy meditsinskoi khimii,
