BIOMAT Database Logo BIOMAT Database Logo

Impact of Serial Intralesional Steroid Injections on Idiopathic Subglottic Stenosis. 2023

Matthew R Hoffman, and Ankita Patro, and Li-Ching Huang, and Sheau-Chiann Chen, and Lynn D Berry, and Alexander Gelbard, and David O Francis, and
Division of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.

Serial intralesional steroid injection (SILSI) has been increasingly used to treat idiopathic subglottic stenosis (iSGS). Prior studies have shown effectiveness, but not in all patients. This multi-institutional study evaluates the effect of SILSI on time to recurrent operation, peak expiratory flow (PEF), and dyspnea. Post-hoc secondary analysis of the North American Airway Collaborative data were performed to evaluate the outcomes of iSGS patients undergoing and not undergoing SILSI. The primary outcome was time to recurrent operation, evaluated using Kaplan-Meier curves and Cox regression analysis. Secondary outcomes were change in PEF and clinical chronic obstructive pulmonary disease questionnaire (CCQ) score. Within patients undergoing SILSI, demographics, time from last procedure, and PEF at initiation of SILSI were evaluated to determine the effect on recurrence. Two hundred and ninety patients were included, 238 undergoing endoscopic dilation alone and 52 undergoing dilation and SILSI. No differences in baseline characteristics were observed. There was no difference in time to recurrence (hazard ratio: 0.64; p = 0.183). There were no differences in PEF or CCQ across the 2.5-year study period. Among 52 patients undergoing SILSI, PEF at the time of starting SILSI did not affect recurrence (χ2  = 0.09, p = 0.77). Patients undergoing and not undergoing SILSI had similar times to recurrence, PEF, and CCQ. Factors predicting recurrence among patients undergoing SILSI were not identified. These results support a randomized controlled trial with a uniform SILSI protocol to quantify the effects of SILSI on objective and subjective outcomes and help determine which iSGS patients benefit most. 3 Laryngoscope, 133:2255-2263, 2023.

UI MeSH Term Description Entries
D007829 Laryngostenosis Developmental or acquired stricture or narrowing of the LARYNX. Symptoms of respiratory difficulty depend on the degree of laryngeal narrowing. Laryngeal Stenosis,Acquired Laryngeal Stenosis,Acquired Subglottic Stenosis,Congenital Subglottic Stenosis,Acquired Laryngeal Stenoses,Acquired Subglottic Stenoses,Congenital Subglottic Stenoses,Laryngeal Stenoses,Laryngeal Stenoses, Acquired,Laryngeal Stenosis, Acquired,Laryngostenoses,Stenoses, Acquired Laryngeal,Stenoses, Acquired Subglottic,Stenoses, Congenital Subglottic,Stenoses, Laryngeal,Stenosis, Acquired Laryngeal,Stenosis, Acquired Subglottic,Stenosis, Congenital Subglottic,Stenosis, Laryngeal,Subglottic Stenoses, Acquired,Subglottic Stenoses, Congenital,Subglottic Stenosis, Acquired,Subglottic Stenosis, Congenital
D003251 Constriction, Pathologic The condition of an anatomical structure's being constricted beyond normal dimensions. Stenosis,Stricture,Constriction, Pathological,Pathologic Constriction,Constrictions, Pathologic,Pathologic Constrictions,Pathological Constriction,Stenoses,Strictures
D004724 Endoscopy Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body. Endoscopic Surgical Procedures,Surgical Procedures, Endoscopic,Endoscopic Surgical Procedure,Endoscopy, Surgical,Surgical Endoscopy,Surgical Procedure, Endoscopic,Procedure, Endoscopic Surgical,Procedures, Endoscopic Surgical
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013256 Steroids A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed) Steroid,Catatoxic Steroids,Steroids, Catatoxic
D015552 Injections, Intralesional Injections introduced directly into localized lesions. Intralesional Injections,Injection, Intralesional,Intralesional Injection
D016896 Treatment Outcome Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series. Rehabilitation Outcome,Treatment Effectiveness,Clinical Effectiveness,Clinical Efficacy,Patient-Relevant Outcome,Treatment Efficacy,Effectiveness, Clinical,Effectiveness, Treatment,Efficacy, Clinical,Efficacy, Treatment,Outcome, Patient-Relevant,Outcome, Rehabilitation,Outcome, Treatment,Outcomes, Patient-Relevant,Patient Relevant Outcome,Patient-Relevant Outcomes

Related Publications

Matthew R Hoffman, and Ankita Patro, and Li-Ching Huang, and Sheau-Chiann Chen, and Lynn D Berry, and Alexander Gelbard, and David O Francis, and
Assessment of side effects after serial intralesional steroid injections for idiopathic subglottic stenosis.
February 2021, European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery,
Matthew R Hoffman, and Ankita Patro, and Li-Ching Huang, and Sheau-Chiann Chen, and Lynn D Berry, and Alexander Gelbard, and David O Francis, and
Voice-Related Quality of Life in Idiopathic Subglottic Stenosis: Effect of Serial Intralesional Steroid Injections.
February 2021, The Laryngoscope,
Matthew R Hoffman, and Ankita Patro, and Li-Ching Huang, and Sheau-Chiann Chen, and Lynn D Berry, and Alexander Gelbard, and David O Francis, and
Serial intralesional steroid injection for subglottic stenosis.
March 2020, The Laryngoscope,
Matthew R Hoffman, and Ankita Patro, and Li-Ching Huang, and Sheau-Chiann Chen, and Lynn D Berry, and Alexander Gelbard, and David O Francis, and
Awake serial intralesional steroid injections without surgery as a novel targeted treatment for idiopathic subglottic stenosis.
March 2018, The Laryngoscope,
Matthew R Hoffman, and Ankita Patro, and Li-Ching Huang, and Sheau-Chiann Chen, and Lynn D Berry, and Alexander Gelbard, and David O Francis, and
Serial office-based steroid injections for treatment of idiopathic subglottic stenosis.
November 2017, The Laryngoscope,
Matthew R Hoffman, and Ankita Patro, and Li-Ching Huang, and Sheau-Chiann Chen, and Lynn D Berry, and Alexander Gelbard, and David O Francis, and
Long-Term Follow-up of 64 Patients With Idiopathic Subglottic Stenosis: Treatment Pathways, Outcomes, and Impact of Serial Intralesional Steroid Injections.
November 2023, The Annals of otology, rhinology, and laryngology,
Matthew R Hoffman, and Ankita Patro, and Li-Ching Huang, and Sheau-Chiann Chen, and Lynn D Berry, and Alexander Gelbard, and David O Francis, and
Systemic safety of serial intralesional steroid injection for subglottic stenosis.
July 2019, The Laryngoscope,
Matthew R Hoffman, and Ankita Patro, and Li-Ching Huang, and Sheau-Chiann Chen, and Lynn D Berry, and Alexander Gelbard, and David O Francis, and
Successful treatment of postintubation subglottic stenosis with intralesional steroid injections.
January 1973, The Annals of thoracic surgery,
Matthew R Hoffman, and Ankita Patro, and Li-Ching Huang, and Sheau-Chiann Chen, and Lynn D Berry, and Alexander Gelbard, and David O Francis, and
Serial In-Office Intralesional Steroid Injections in Airway Stenosis.
March 2018, JAMA otolaryngology-- head & neck surgery,
Matthew R Hoffman, and Ankita Patro, and Li-Ching Huang, and Sheau-Chiann Chen, and Lynn D Berry, and Alexander Gelbard, and David O Francis, and
Serial Intralesional Steroid Injection for Subglottic Stenosis: Systemic Side Effects and Impact on Surgery-Free Interval.
January 2021, OTO open,
Copied contents to your clipboard!