Screening and Bioinformatics Analysis of Crucial Gene of Heart Failure and Atrial Fibrillation Based on GEO Database. 2022

Yuansong Zhuang, and Zhentao Qiao, and Xuanye Bi, and Dongjian Han, and Qingjiao Jiang, and Yi Zhang, and Fuhang Wang, and Miaomiao Liu, and Quanxu An, and Jiahong Shangguan, and Deliang Shen
Cardiology Department, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Background and objectives: In clinical practice, we observed that the prognoses of patients with heart failure and atrial fibrillation were worse than those of patients with only heart failure or atrial fibrillation. The study aims to get a better understanding of the common pathogenesis of the two diseases and find new therapeutic targets. Materials and Methods: We downloaded heart failure datasets and atrial fibrillation datasets from the gene expression omnibus database. The common DEGs (differentially expressed genes) in heart failure and atrial fibrillation were identified by a series of bioinformatics methods. To better understand the functions and possible pathways of DEGs, we performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Results: We identified 22 up-regulated genes and 14 down-regulated genes in two datasets of heart failure and 475 up-regulated and 110 down-regulated genes in atrial fibrillation datasets. In addition, two co-upregulated (FRZB, SFRP4) and three co-downregulated genes (ENTPPL, AQP4, C1orf105) were identified. GO enrichment results showed that these common differentially expressed genes were mainly concentrated in the signal regulation of the Wnt pathway. Conclusions: We found five crucial genes in heart failure and atrial fibrillation, which may be potential therapeutic targets for patients with heart failure and atrial fibrillation.

UI MeSH Term Description Entries
D006333 Heart Failure A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION. Cardiac Failure,Heart Decompensation,Congestive Heart Failure,Heart Failure, Congestive,Heart Failure, Left-Sided,Heart Failure, Right-Sided,Left-Sided Heart Failure,Myocardial Failure,Right-Sided Heart Failure,Decompensation, Heart,Heart Failure, Left Sided,Heart Failure, Right Sided,Left Sided Heart Failure,Right Sided Heart Failure
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001281 Atrial Fibrillation Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation. Auricular Fibrillation,Familial Atrial Fibrillation,Paroxysmal Atrial Fibrillation,Persistent Atrial Fibrillation,Atrial Fibrillation, Familial,Atrial Fibrillation, Paroxysmal,Atrial Fibrillation, Persistent,Atrial Fibrillations,Atrial Fibrillations, Familial,Atrial Fibrillations, Paroxysmal,Atrial Fibrillations, Persistent,Auricular Fibrillations,Familial Atrial Fibrillations,Fibrillation, Atrial,Fibrillation, Auricular,Fibrillation, Familial Atrial,Fibrillation, Paroxysmal Atrial,Fibrillation, Persistent Atrial,Fibrillations, Atrial,Fibrillations, Auricular,Fibrillations, Familial Atrial,Fibrillations, Paroxysmal Atrial,Fibrillations, Persistent Atrial,Paroxysmal Atrial Fibrillations,Persistent Atrial Fibrillations
D015972 Gene Expression Regulation, Neoplastic Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue. Neoplastic Gene Expression Regulation,Regulation of Gene Expression, Neoplastic,Regulation, Gene Expression, Neoplastic
D053263 Gene Regulatory Networks Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations. Gene Circuits,Gene Modules,Gene Networks,Transcriptional Networks,Gene Module,Circuit, Gene,Circuits, Gene,Gene Circuit,Gene Network,Gene Regulatory Network,Module, Gene,Modules, Gene,Network, Gene,Network, Gene Regulatory,Network, Transcriptional,Networks, Gene,Networks, Gene Regulatory,Networks, Transcriptional,Regulatory Network, Gene,Regulatory Networks, Gene,Transcriptional Network
D019295 Computational Biology A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets. Bioinformatics,Molecular Biology, Computational,Bio-Informatics,Biology, Computational,Computational Molecular Biology,Bio Informatics,Bio-Informatic,Bioinformatic,Biologies, Computational Molecular,Biology, Computational Molecular,Computational Molecular Biologies,Molecular Biologies, Computational
D020869 Gene Expression Profiling The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell. Gene Expression Analysis,Gene Expression Pattern Analysis,Transcript Expression Analysis,Transcriptome Profiling,Transcriptomics,mRNA Differential Display,Gene Expression Monitoring,Transcriptome Analysis,Analyses, Gene Expression,Analyses, Transcript Expression,Analyses, Transcriptome,Analysis, Gene Expression,Analysis, Transcript Expression,Analysis, Transcriptome,Differential Display, mRNA,Differential Displays, mRNA,Expression Analyses, Gene,Expression Analysis, Gene,Gene Expression Analyses,Gene Expression Monitorings,Gene Expression Profilings,Monitoring, Gene Expression,Monitorings, Gene Expression,Profiling, Gene Expression,Profiling, Transcriptome,Profilings, Gene Expression,Profilings, Transcriptome,Transcript Expression Analyses,Transcriptome Analyses,Transcriptome Profilings,mRNA Differential Displays

Related Publications

Yuansong Zhuang, and Zhentao Qiao, and Xuanye Bi, and Dongjian Han, and Qingjiao Jiang, and Yi Zhang, and Fuhang Wang, and Miaomiao Liu, and Quanxu An, and Jiahong Shangguan, and Deliang Shen
December 2022, Journal of thoracic disease,
Yuansong Zhuang, and Zhentao Qiao, and Xuanye Bi, and Dongjian Han, and Qingjiao Jiang, and Yi Zhang, and Fuhang Wang, and Miaomiao Liu, and Quanxu An, and Jiahong Shangguan, and Deliang Shen
July 2023, BMC cardiovascular disorders,
Yuansong Zhuang, and Zhentao Qiao, and Xuanye Bi, and Dongjian Han, and Qingjiao Jiang, and Yi Zhang, and Fuhang Wang, and Miaomiao Liu, and Quanxu An, and Jiahong Shangguan, and Deliang Shen
June 2023, European review for medical and pharmacological sciences,
Yuansong Zhuang, and Zhentao Qiao, and Xuanye Bi, and Dongjian Han, and Qingjiao Jiang, and Yi Zhang, and Fuhang Wang, and Miaomiao Liu, and Quanxu An, and Jiahong Shangguan, and Deliang Shen
January 2019, BioMed research international,
Yuansong Zhuang, and Zhentao Qiao, and Xuanye Bi, and Dongjian Han, and Qingjiao Jiang, and Yi Zhang, and Fuhang Wang, and Miaomiao Liu, and Quanxu An, and Jiahong Shangguan, and Deliang Shen
November 2023, Studies in health technology and informatics,
Yuansong Zhuang, and Zhentao Qiao, and Xuanye Bi, and Dongjian Han, and Qingjiao Jiang, and Yi Zhang, and Fuhang Wang, and Miaomiao Liu, and Quanxu An, and Jiahong Shangguan, and Deliang Shen
January 2020, Zhonghua yi xue za zhi,
Yuansong Zhuang, and Zhentao Qiao, and Xuanye Bi, and Dongjian Han, and Qingjiao Jiang, and Yi Zhang, and Fuhang Wang, and Miaomiao Liu, and Quanxu An, and Jiahong Shangguan, and Deliang Shen
July 2023, Zhonghua xin xue guan bing za zhi,
Yuansong Zhuang, and Zhentao Qiao, and Xuanye Bi, and Dongjian Han, and Qingjiao Jiang, and Yi Zhang, and Fuhang Wang, and Miaomiao Liu, and Quanxu An, and Jiahong Shangguan, and Deliang Shen
August 2020, Medical science monitor : international medical journal of experimental and clinical research,
Yuansong Zhuang, and Zhentao Qiao, and Xuanye Bi, and Dongjian Han, and Qingjiao Jiang, and Yi Zhang, and Fuhang Wang, and Miaomiao Liu, and Quanxu An, and Jiahong Shangguan, and Deliang Shen
January 2021, Pharmacogenomics and personalized medicine,
Yuansong Zhuang, and Zhentao Qiao, and Xuanye Bi, and Dongjian Han, and Qingjiao Jiang, and Yi Zhang, and Fuhang Wang, and Miaomiao Liu, and Quanxu An, and Jiahong Shangguan, and Deliang Shen
October 2021, Journal of clinical medicine,
Copied contents to your clipboard!