[Physicochemical and pharmacokinetic research on Pharmachim's thiabendazole]. 1987

P Dilov, and E Chaleva, and S Radulova, and M Iotsev

Studied was the preparation thiabendazole-Pharmachim (TBZ-Ph), produced by the Economic Corporation "Pharmachim". In some of the experiments TBZ-Ph was comparatively studied with the Merck & Sharp and Dom preparation (TBZ-MShD), Switzerland. It was found that the light absorption maximum of TBZ-Ph was at 302 nm. Thermostability studies revealed that the preparation was comparatively stable in the course of 6 months at room temperature and at 4 degrees and 40 degrees C. When stored in the form of 1 per cent medicated feed at room t degrees, 4 degrees, and 40 degrees C it showed no deviations as against the check samples over a period of 70 days. TBZ-Ph was shown to possess slight photosensitivity; it was not hygroscopic. In oral administration to sheep and pigs at the rate of 100 mg per kg body mass, in the form of a 10 per cent water suspension TBZ-Ph was absorbed through the gastro-intestinal membrane. It was retained in the blood serum of sheep up to the 24th hour. The preparation was shown to gain access to almost all viscera and striated muscles, persisting in them for some twenty days. Following the oral application in a dose of 100 mg/kg it reached the mammary gland of lactating ewes and was detected in the milk in maximum concentrations as early as the 3rd hour (5.8 to 12.3 ppm); in the course of the following hours concentrations dropped, and in individual animals the preparation was traced up to the 96th hour.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D007774 Lactation The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN. Lactation, Prolonged,Milk Secretion,Lactations, Prolonged,Milk Secretions,Prolonged Lactation,Prolonged Lactations
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D001822 Body Burden The total amount of a chemical, metal or radioactive substance present at any time after absorption in the body of man or animal. Body Burdens,Burden, Body,Burdens, Body
D002031 Bulgaria A country in Southeastern Europe, bordering the Black Sea, between Romania and Turkey. The capital is Sofia.
D002627 Chemistry, Physical The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes. Physical Chemistry,Chemistries, Physical,Physical Chemistries
D002645 Chickens Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA. Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D004531 Eggs Animal reproductive bodies, or the contents thereof, used as food. The concept is differentiated from OVUM, the anatomic or physiologic entity.
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

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