BIOMAT Database Logo BIOMAT Database Logo

[Bronchodilating effect of terbutaline inhaled with and without a tube spacer in asthmatic children]. 1987

C Vázquez Cordero, and M Ubetagoyena Arrieta, and A Bilbao Aburto, and P Gutiérrez Mazorriaga

Eighteen children aged 10.3 +/- 2.4 years who needed regular use of antiasthmatic drugs and showed after abandoning them with the appropriate intervals a FEV1 below 85% of their highest previous value, received in a randomized, double-blind crossover fashion two puffs of terbutaline 1 hour apart on two consecutive days. The drug was administered either with the conventional inhaler or a 10.3 X 2 cm. Forced spirometry, peak flow, flow-volume loops, and whole body plethysmography were performed basally, and 5, 15 and 45 minutes after each puff. The peak increase of the FEV1 was greater with the spacer (41.7% vs 30.4%, p less than 0.05). The increase of FEV1 was higher with the spacer at 5 minutes following the first puff and at 15 and 45 minutes after the second puff. No difference was observed in the other variables measured. Sixteen inhaled the drug "coordinatedly". The spacer offers some advantage in asthmatic children who inhale terbutaline mostly in a coordinated way.

UI MeSH Term Description Entries
D008297 Male Males
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D005260 Female Females
D005541 Forced Expiratory Volume Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity. Forced Vital Capacity, Timed,Timed Vital Capacity,Vital Capacity, Timed,FEVt,Capacities, Timed Vital,Capacity, Timed Vital,Expiratory Volume, Forced,Expiratory Volumes, Forced,Forced Expiratory Volumes,Timed Vital Capacities,Vital Capacities, Timed,Volume, Forced Expiratory,Volumes, Forced Expiratory
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000280 Administration, Inhalation The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract. Drug Administration, Inhalation,Drug Administration, Respiratory,Drug Aerosol Therapy,Inhalation Drug Administration,Inhalation of Drugs,Respiratory Drug Administration,Aerosol Drug Therapy,Aerosol Therapy, Drug,Drug Therapy, Aerosol,Inhalation Administration,Administration, Inhalation Drug,Administration, Respiratory Drug,Therapy, Aerosol Drug,Therapy, Drug Aerosol
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D001249 Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Asthma, Bronchial,Bronchial Asthma,Asthmas
D013726 Terbutaline A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic. Arubendol,Asthmoprotect,Brethaire,Brethine,Bricanyl,Bricanyl SA,Butaliret,Butalitab,Contimit,KWD-2019,Monovent,Taziken,Tedipulmo,Terbasmin,Terbul,Terbutalin AL,Terbutalin Stada,Terbutalin-ratiopharm,Terbutaline Sulfate,Terbuturmant,terbutalin von ct,KWD 2019,KWD2019,Terbutalin ratiopharm

Related Publications

C Vázquez Cordero, and M Ubetagoyena Arrieta, and A Bilbao Aburto, and P Gutiérrez Mazorriaga
Comparison of salbutamol powder with terbutaline aerosol administered with a tube spacer in asthmatic children.
December 1983, Australian paediatric journal,
C Vázquez Cordero, and M Ubetagoyena Arrieta, and A Bilbao Aburto, and P Gutiérrez Mazorriaga
Comparison of inhaled terbutaline and inhaled terbutaline plus ipratropium bromide in acute asthmatic children.
June 1990, Asian Pacific journal of allergy and immunology,
C Vázquez Cordero, and M Ubetagoyena Arrieta, and A Bilbao Aburto, and P Gutiérrez Mazorriaga
Inhaled ipratropium bromide and terbutaline in asthmatic children.
February 1993, Respiratory medicine,
C Vázquez Cordero, and M Ubetagoyena Arrieta, and A Bilbao Aburto, and P Gutiérrez Mazorriaga
Bronchodilating effect of terbutaline aerosol.
June 1978, Clinical pharmacology and therapeutics,
C Vázquez Cordero, and M Ubetagoyena Arrieta, and A Bilbao Aburto, and P Gutiérrez Mazorriaga
Comparison of inhaled terbutaline and terbutaline injection in treatment of acute asthmatic attacks in children.
June 1989, Asian Pacific journal of allergy and immunology,
C Vázquez Cordero, and M Ubetagoyena Arrieta, and A Bilbao Aburto, and P Gutiérrez Mazorriaga
Adrenal suppression among asthmatic children receiving chronic therapy with inhaled corticosteroid with and without spacer device.
March 1996, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology,
C Vázquez Cordero, and M Ubetagoyena Arrieta, and A Bilbao Aburto, and P Gutiérrez Mazorriaga
Salbutamol: comparison of bronchodilating effect of inhaled powder and aerosol in asthmatic subjects.
November 1982, Canadian Medical Association journal,
C Vázquez Cordero, and M Ubetagoyena Arrieta, and A Bilbao Aburto, and P Gutiérrez Mazorriaga
Treatment of chronic bronchitis with terbutaline inhaled from a cone spacer with and without positive expiratory pressure.
January 1991, Lung,
C Vázquez Cordero, and M Ubetagoyena Arrieta, and A Bilbao Aburto, and P Gutiérrez Mazorriaga
Optimal use of tube spacer aerosols in asthmatic children.
September 1985, Clinical allergy,
C Vázquez Cordero, and M Ubetagoyena Arrieta, and A Bilbao Aburto, and P Gutiérrez Mazorriaga
Bronchodilator effect of terbutaline aerosol in asthmatic: comparison of two spacer devices.
January 1990, The Indian journal of chest diseases & allied sciences,
Copied contents to your clipboard!