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The biliary excretion of ouabain was examined in Fischer-344 rats of both sexes and of different ages. The biliary recoveries for the first 10-min period after the intravenous injection of ouabain (0.1 mg/100 g body weight) were nearly 2-fold higher in female than in male rats for all age groups compared (4, 6, 12, 24, 28 months). In both sexes, the biliary recovery showed a gradual decrease with age, and the first 10-min value in 24-months old rats was about one third of those in the youngest rats. The 60-min total recovery values also significantly decreased with age. Some very old (males, 28 months; females, 31 months) rats, however, showed higher 60-min total recovery values than younger rats comparable to the youngest animal values. It was concluded that the biliary excretion of ouabain in rats decreases with age in both sexes which suggests that this is a general phenomenon in this animal species.
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